2-[4-[[2-[(2E)-2-[1-(7-fluoro-1-benzothiophen-3-yl)-3-methoxypropylidene]hydrazinyl]-2-oxoethyl]carbamoyl]-2-methoxyphenoxy]ethyl (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-[4-[[2-[(2E)-2-[1-(7-fluoro-1-benzothiophen-3-yl)-3-methoxypropylidene]hydrazinyl]-2-oxoethyl]carbamoyl]-2-methoxyphenoxy]ethyl (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoate
• 化学式: C₄₄H₄₅FN₄O₉S
• 分子量: 824.9
• InChiKey: ATSXBXQYBXABBM-LLDWUJJDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  59
• 可旋转键数：
  20
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  191
• 氢给体数：
  3
• 氢受体数：
  12

文献信息

• [EN] COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS<br/>[FR] COMPOSÉS POUR LE TRAITEMENT D'INFECTIONS VIRALES PAR PARAMYXOVIRUS
  申请人：ALIOS BIOPHARMA INC

  公开号：WO2014031784A1

  公开（公告）日：2014-02-27

  Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

  本文披露了新的抗病毒化合物，以及包含一种或多种抗病毒化合物的药物组合物，并且揭示了合成这些化合物的方法。本文还披露了利用一种或多种小分子化合物改善和/或治疗副黏病毒病毒感染的方法。副黏病毒感染的例子包括由人类呼吸道合胞病毒（RSV）引起的感染。
• COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS
  申请人：Alios BioPharma, Inc.

  公开号：US20170283429A1

  公开（公告）日：2017-10-05

  Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
• US9724351B2
  申请人：——

  公开号：US9724351B2

  公开（公告）日：2017-08-08