7-Iodo-1,3-dimethylpurine-2,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-Iodo-1,3-dimethylpurine-2,6-dione
• 英文别名: 7-iodo-1,3-dimethylpurine-2,6-dione
• 化学式: C₇H₇IN₄O₂
• 分子量: 306.06
• InChiKey: BDVKLUQLWBRKKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  58.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• METHODS
  申请人：Arterius Limited

  公开号：EP3345739A2

  公开（公告）日：2018-07-11

  Bioresorbable polymeric tubes suitable for use in a stent have been produced by a using a novel die drawing technique.

  通过使用一种新颖的模具拉伸技术，生产出了适用于支架的生物可吸收聚合物管。
• Method of producing a tube for use in the formation of a stent, and such tube
  申请人：Arterius Limited

  公开号：US10299944B2

  公开（公告）日：2019-05-28

  Bioresorbable polymeric tubes suitable for use in a stent have been produced by a using a die drawing technique, comprising: —deforming an orientable, thermoplastic polymer tubing (4) in the solid phase by drawing it over a mandrel (1) and/or through a die (3), where the mandrel (1) has a lead end and an exit end and the die (3) has an entry side and an exit side, wherein a drawing mechanism applies a drawing tension to the tubing (4) from the exit end of the mandrel (1) and/or the exit side of the die (3), said tension being insufficient to cause tensile failure of the tubing but sufficient to deform the tubing, thereby drawing the tubing over the mandrel (1) and/or through the die (3) in the solid phase to induce uniaxial or biaxial orientation of the polymer; and —collecting the deformed tubing from the exit end of the mandrel (1) and/or the exit side of the die (3).

  适用于支架的生物可吸收聚合物管是通过使用模具拉伸技术生产的，该技术包括-通过在心轴（1）上和/或通过模具（3）拉伸固相中的可定向热塑性聚合物管（4），使其变形，其中心轴（1）具有导端和出口端，模具（3）具有入口侧和出口侧，其中拉伸机构从心轴（1）的出口端和/或模具（3）的出口侧向管（4）施加拉伸张力、所述拉力不足以导致管材拉伸失效，但足以使管材变形，从而将管材拉过心轴 (1) 和/或通过固相模具 (3)，以诱导聚合物的单轴或双轴取向；从芯轴 (1) 的出口端和/或模具 (3) 的出口侧收集变形管材。
• EP2909003A1
  申请人：——

  公开号：EP2909003A1

  公开（公告）日：2015-08-26
• Method Of Producing A Tube For Use In The Formation Of A Stent, And Such Tube
  申请人：ARTERIUS LIMITED

  公开号：US20150230946A1

  公开（公告）日：2015-08-20

  Bioresorbable polymeric tubes suitable for use in a stent have been produced by a using a die drawing technique, comprising: —deforming an orientable, thermoplastic polymer tubing ( 4 ) in the solid phase by drawing it over a mandrel ( 1 ) and/or through a die ( 3 ), where the mandrel ( 1 ) has a lead end and an exit end and the die ( 3 ) has an entry side and an exit side, wherein a drawing mechanism applies a drawing tension to the tubing ( 4 ) from the exit end of the mandrel ( 1 ) and/or the exit side of the die ( 3 ), said tension being insufficient to cause tensile failure of the tubing but sufficient to deform the tubing, thereby drawing the tubing over the mandrel ( 1 ) and/or through the die ( 3 ) in the solid phase to induce uniaxial or biaxial orientation of the polymer; and —collecting the deformed tubing from the exit end of the mandrel ( 1 ) and/or the exit side of the die ( 3 ).
• [EN] METHOD OF PRODUCING A TUBE FOR USE IN THE FORMATION OF A STENT, AND SUCH TUBE<br/>[FR] PROCÉDÉ DE PRODUCTION D'UN TUBE DESTINÉ À ÊTRE UTILISÉ DANS LA FORMATION D'UNE ENDOPROTHÈSE, ET TUBE
  申请人：ARTERIUS LTD

  公开号：WO2014045068A1

  公开（公告）日：2014-03-27

  Bioresorbable polymeric tubes suitable for use in a stent have been produced by a using a die drawing technique, comprising: - deforming an orientable, thermoplastic polymer tubing (4) in the solid phase by drawing it over a mandrel (1) and/or through a die (3), where the mandrel (1) has a lead end and an exit end and the die (3) has an entry side and an exit side, wherein a drawing mechanism applies a drawing tension to the tubing (4) from the exit end of the mandrel (1) and/or the exit side of the die (3), said tension being insufficient to cause tensile failure of the tubing but sufficient to deform the tubing, thereby drawing the tubing over the mandrel (1) and/or through the die (3) in the solid phase to induce uniaxial or biaxial orientation of the polymer; and - collecting the deformed tubing from the exit end of the mandrel (1) and/or the exit side of the die (3).