(S)-2,2'-dimethoxy-1,1'-binaphthyl-6,6'-diamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-2,2'-dimethoxy-1,1'-binaphthyl-6,6'-diamine
• 英文别名: 5-(6-Amino-2-methoxynaphthalen-1-yl)-6-methoxynaphthalen-2-amine；5-(6-amino-2-methoxynaphthalen-1-yl)-6-methoxynaphthalen-2-amine
• 化学式: C₂₂H₂₀N₂O₂
• 分子量: 344.413
• InChiKey: SKJJASOTTPBFDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  70.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4,7-Bis(2-methylpropoxy)-9-(phenylcarbamoyl)-1,10-phenanthroline-2-carboxylic acid 、 (S)-2,2'-dimethoxy-1,1'-binaphthyl-6,6'-diamine 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以83%的产率得到9-[[5-[6-[[9-(C-hydroxy-N-phenylcarbonimidoyl)-4,7-bis(2-methylpropoxy)-1,10-phenanthroline-2-carbonyl]amino]-2-methoxynaphthalen-1-yl]-6-methoxynaphthalen-2-yl]carbamoyl]-4,7-bis(2-methylpropoxy)-N-phenyl-1,10-phenanthroline-2-carboximidic acid
  参考文献：
  名称：

  A Helix−Turn−Helix Supersecondary Structure Based on Oligo(phenanthroline dicarboxamide)s

  摘要：

  An artificial helix-turn-helix (HTH) supersecondary structure based on the oligo(phenanthroline dicarboxamide)s, in which the 2,2'-dimethoxy-1,1'-binaphthyl-6,6'-diamine subunit was utilized as the turn to impart a bias in the twist sense of the supersecondary structure, was reported. The HTH structure has been demonstrated by UV/vis, NMR, CD spectra, and X-ray crystal analysis.

  DOI：

  10.1021/ol702720q
• 作为产物：
  描述：

  S-/R-2,2'-dimethoxy-6,6'-dinitro-1,1'-binaphthalene 在 palladium on activated charcoal 氢气 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 20.0 ℃ 、400.01 kPa 条件下， 反应 4.0h， 生成 (S)-2,2'-dimethoxy-1,1'-binaphthyl-6,6'-diamine
  参考文献：
  名称：

  A Helix−Turn−Helix Supersecondary Structure Based on Oligo(phenanthroline dicarboxamide)s

  摘要：

  An artificial helix-turn-helix (HTH) supersecondary structure based on the oligo(phenanthroline dicarboxamide)s, in which the 2,2'-dimethoxy-1,1'-binaphthyl-6,6'-diamine subunit was utilized as the turn to impart a bias in the twist sense of the supersecondary structure, was reported. The HTH structure has been demonstrated by UV/vis, NMR, CD spectra, and X-ray crystal analysis.

  DOI：

  10.1021/ol702720q

文献信息

• A Helix−Turn−Helix Supersecondary Structure Based on Oligo(phenanthroline dicarboxamide)s
  作者：Hai-Yu Hu、Jun-Feng Xiang、Yong Yang、Chuan-Feng Chen

  DOI：10.1021/ol702720q

  日期：2008.1.1

  An artificial helix-turn-helix (HTH) supersecondary structure based on the oligo(phenanthroline dicarboxamide)s, in which the 2,2'-dimethoxy-1,1'-binaphthyl-6,6'-diamine subunit was utilized as the turn to impart a bias in the twist sense of the supersecondary structure, was reported. The HTH structure has been demonstrated by UV/vis, NMR, CD spectra, and X-ray crystal analysis.