butan-2-yl 4-hydroxybenzoate;1,3-dimethyl-7H-purine-2,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: butan-2-yl 4-hydroxybenzoate;1,3-dimethyl-7H-purine-2,6-dione
• 化学式: C18H22N4O5
• 分子量: 374.4
• InChiKey: IIZHXOKZAJTZKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.31
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell
  申请人：Cyrano Therapeutics, Inc.

  公开号：US10598672B2

  公开（公告）日：2020-03-24

  Disclosed herein are methods for diagnosing a subject with loss and/or distortion of taste or smell, e.g., hyposmia, dysosmia, anosmia, phantosmia, hypogeusia, dysgeusia, phantogeusia, and/or ageusia. Also disclosed herein are methods and compositions for treating a subject for loss and/or distortion of taste or smell, e.g., hyposmia, dysosmia, anosmia, phantosmia, hypogeusia, dysgeusia, phantogeusia, and/or ageusia.

  本文公开了用于诊断味觉或嗅觉丧失和/或失真（如嗅觉减退、嗅觉障碍、无嗅觉、幻嗅觉、低嗅觉、失嗅觉、幻嗅觉和/或老嗅觉）的方法。本文还公开了用于治疗受试者味觉或嗅觉丧失和/或扭曲的方法和组合物，例如，味觉减退症、味觉失调症、无嗅症、幻觉症、味觉减退症、味觉失调症、幻觉症和/或老年性味觉失调症。
• PHOSPHODIESTERASE INHIBITORS FOR TREATING TASTE AND SMELL DISORDERS
  申请人：Henkin, Robert I.

  公开号：EP2903619A1

  公开（公告）日：2015-08-12
• PHOSPHODIESTERASE INHIBITOR TREATMENT
  申请人：Henkin, Robert I.

  公开号：EP2968204A1

  公开（公告）日：2016-01-20
• METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING LOSS AND/OR DISTORTION OF TASTE OR SMELL
  申请人：Henkin, Robert I.

  公开号：EP3108245A1

  公开（公告）日：2016-12-28
• Phosphodiesterase Inhibitor Treatment
  申请人：Cyrano Therapeutics, Inc.

  公开号：US20220226332A1

  公开（公告）日：2022-07-21

  Methods and compositions are disclosed for the treatment of taste and smell disorders. The compositions comprise phosphodiesterase inhibitors and are formulated for intranasal administration.