N-[5-(2-aminoethyl)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,6-dioxopyrimidin-1-yl]prop-2-enamide

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: N-[5-(2-aminoethyl)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,6-dioxopyrimidin-1-yl]prop-2-enamide
• 化学式: C₁₄H₂₀N₄O₆
• 分子量: 340.33
• InChiKey: IDLJLISGMYVRBB-HOSYDEDBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  145
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• METHODS OF X-APTAMER GENERATION AND COMPOSITIONS THEREOF
  申请人：AM Biotechnologies, LLC

  公开号：US20140100120A1

  公开（公告）日：2014-04-10

  Provided herein are methods for a novel bead-based next-generation “X-aptamer” selection scheme that extends aptamer technology to include X-modified bases, thus resulting in X-aptamers, at any position along the sequence because the aptamers are chemically synthesized via a split-pool scheme on individual beads. Also provides are application to a wide range of commonly used DNA modifications, including, but not limited to, monothioate and dithioate backbone substitutions. This new class of aptamer allows chemical modifications introduced to any of the bases in the aptamer sequence as well as the phosphate backbones and can be extended to other carbohydrate-based systems.
• US9988623B2
  申请人：——

  公开号：US9988623B2

  公开（公告）日：2018-06-05