9H-fluoren-9-ylmethyl N-(1-aminobutyl)carbamate;hydrobromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9H-fluoren-9-ylmethyl N-(1-aminobutyl)carbamate;hydrobromide
• 化学式: C19H23BrN2O2
• 分子量: 391.3
• InChiKey: VJHWBCKPARZXFN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.19
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  64.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] POLYETHYLENIMINE (PEI)-POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF<br/>[FR] CONJUGUÉS POLYÉTHYLÈNIMINE (PEI)-POLYPEPTIDE ET LEURS MÉTHODES D'UTILISATION
  申请人：APG THERAPEUTICS INC

  公开号：WO2017120536A1

  公开（公告）日：2017-07-13

  The present application provides PEI compounds comprising a linker, PEI-polypeptide conjugates (e.g., PEI-antibody conjugates), and complexes thereof comprising a biologically active molecule. Methods of preparing and using the compounds, conjugates and complexes are further provided. The PEI-polypeptide conjugates and complexes are useful for delivering biologically active molecules to the cytoplasm of cells and promoting release of the biologically active molecules from the endo-lysosomal pathway.

  本申请提供了包含连接剂的PEI化合物，PEI-多肽结合物（例如PEI-抗体结合物）以及包含生物活性分子的复合物。此外还提供了制备和使用这些化合物、结合物和复合物的方法。PEI-多肽结合物和复合物可用于将生物活性分子传递到细胞质并促进其从内质网溶酶体途径中释放。
• POLYMER CONJUGATE VACCINES
  申请人：The University of Chicago

  公开号：EP3356371A1

  公开（公告）日：2018-08-08
• [EN] MORPHINE-6-GLUCURONIDE DERIVATIVES, IMMUNOGENS AND IMMUNOASSAY<br/>[FR] DÉRIVÉS DE MORPHINE-6-GLUCURONIDE, IMMUNOGÈNES ET DOSAGE IMMUNOLOGIQUE
  申请人：CISBIO BIOASSAYS

  公开号：WO2014053603A1

  公开（公告）日：2014-04-10

  The invention relates to compounds of formula (I); wherein A and L are as defined in the description. The invention also relates to immunogens obtained from said compounds, and to antibodies raised against said immunogens. The compounds of the invention are used to detect M6G in biological fluids.
• [EN] METHODS AND COMPOSITIONS FOR TREATING CANCER WITH CANCER-TARGETED ADJUVANTS<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DU CANCER AVEC DES ADJUVANTS CIBLANT LE CANCER
  申请人：UNIV CHICAGO

  公开号：WO2020247973A1

  公开（公告）日：2020-12-10

  Here, the inventors describe methods and compositions for targeting a TLR agonist to the tumor cell or stroma. Aspects of the disclosure relate to a polypeptide comprising a tumor targeting agent operatively linked to p(Man-TLR). Also disclosed are compositions and methods for treating cancer in a subject comprising administration of the polypeptide comprising the tumor targeting agent linked to p(Man-TLR) to the subject.