3-amino-1-[(2R,4R,5R)-3,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 3-amino-1-[(2R,4R,5R)-3,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• 化学式: C₉H₁₃N₃O₇
• 分子量: 275.22
• InChiKey: MIRQOOPFHUWMHZ-QPPQHZFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  157
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• C-MYC ANTISENSE OLIGONUCLEOTIDES AND METHODS FOR USING THE SAME TO TREAT CELL-PROLIFERATIVE DISORDERS
  申请人：Geron Corporation

  公开号：EP2912179A1

  公开（公告）日：2015-09-02
• [EN] C-MYC ANTISENSE OLIGONUCLEOTIDES AND METHODS FOR USING THE SAME TO TREAT CELL-PROLIFERATIVE DISORDERS<br/>[FR] OLIGONUCLÉOTIDES ANTISENS C-MYC ET SES PROCÉDÉS D'UTILISATION POUR LE TRAITEMENT DE TROUBLES DE LA PROLIFÉRATION CELLULAIRE
  申请人：GERON CORP

  公开号：WO2014066851A1

  公开（公告）日：2014-05-01

  Provided herein are antisense oligonucleotides that can effectively prevent or decrease c-myc protein expression as well as decrease overall rates of cell proliferation in in vitro and mammalian in vivo models of cell proliferative disorders as well as methods for using the same. The antisense oligonucleotides comprise at least one phosphoramidate (NP)-modified or thiophosphoramidate (NPS)-modified intersubunit linkage.