2-(1,3-Dioxoisoindol-2-yl)ethylcarbamic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(1,3-Dioxoisoindol-2-yl)ethylcarbamic acid
• 英文别名: 2-(1,3-dioxoisoindol-2-yl)ethylcarbamic acid
• 化学式: C₁₁H₁₀N₂O₄
• 分子量: 234.21
• InChiKey: ZYEDMEREDLKZBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  86.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20140128372A1

  公开（公告）日：2014-05-08

  The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

  本申请涉及新型取代咪唑[1,2-a]吡啶-3-羧酰胺，其制备方法，单独或组合使用以治疗和/或预防疾病，以及用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
• AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20150274719A1

  公开（公告）日：2015-10-01

  The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

  本申请涉及新型取代的咪唑并[1,2-a]吡啶-3-羧酰胺，其制备方法，其单独或与其他药物联合用于治疗和/或预防疾病，以及其用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
• NANOPARTICLES FOR DRUG DELIVERY
  申请人：University of Louisville Research Foundation, Inc.

  公开号：US20180185512A1

  公开（公告）日：2018-07-05

  The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles.
• US9126998B2
  申请人：——

  公开号：US9126998B2

  公开（公告）日：2015-09-08
• [EN] NANOPARTICLES FOR DRUG DELIVERY<br/>[FR] NANOPARTICULES POUR L'ADMINISTRATION DE MÉDICAMENT
  申请人：UNIV LOUISVILLE RES FOUND

  公开号：WO2014124329A1

  公开（公告）日：2014-08-14

  The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles. An important attribute of a drug delivery system is its ability to allow for spatial and temporal regulated drug release, thereby minimizing side effects and improving therapeutic efficacy of conventional pharmaceuticals. Iron oxide nanoparticles (NPs ), specifically Fe304 nanoparticles, possess many appropriate qualities that make them a viable choice for drug delivery.