[[2-[1-(6-Aminopurin-9-yl)propan-2-yloxymethyl]phenyl]peroxy-hydroxyphosphoryl]oxymethyl 2,2-dimethylpropanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: [[2-[1-(6-Aminopurin-9-yl)propan-2-yloxymethyl]phenyl]peroxy-hydroxyphosphoryl]oxymethyl 2,2-dimethylpropanoate
• 英文别名: [[2-[1-(6-aminopurin-9-yl)propan-2-yloxymethyl]phenyl]peroxy-hydroxyphosphoryl]oxymethyl 2,2-dimethylpropanoate
• 化学式: C₂₁H₂₈N₅O₈P
• 分子量: 509.4
• InChiKey: NKXTXCLTZMUHTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  35
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  170
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• [EN] SALTS OF ANTIVIRAL PHOSPHONATE ANALOGUES AND PROCESS FOR PREPARATION THEREOF<br/>[FR] SELS D'ANALOGUES DE PHOSPHONATE ANTIVIRAUX ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：CIPLA LTD

  公开号：WO2018167515A1

  公开（公告）日：2018-09-20

  The present invention relates to certain acid salts of (((1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methyl)(phenoxy) phosphoryloxy)methyl pivalateof Formula (I), to processes for their preparation; to pharmaceutical compositions comprising such compounds,and methods of treating a disease which responds to inhibition of nucleotide reverse transcriptase activity.

  本发明涉及一种特定的酸盐，化学式为(((1-(6-氨基-9H-嘌呤-9-基)丙基氧基)甲基(苯氧基)磷酰氧基)甲基)季戊酸盐(I)，以及其制备方法；包含这类化合物的药物组合物；以及治疗对核苷酸逆转录酶活性抑制有响应的疾病的方法。
• [EN] ANTIVIRAL PHOSPHONATE ANALOGUES AND PROCESS FOR PREPARATION THEREOF<br/>[FR] ANALOGUES DE PHOSPHONATE ANTIVIRAUX ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：CIPLA LTD

  公开号：WO2014068265A1

  公开（公告）日：2014-05-08

  The present invention provides a compound of the Formula (I) wherein R is 9-isopropyl-9H-purin-6-amine; 2-amino-9-isopropyl-lH-purin-6(9H)-one; 4-amino- 1-isopropyl pyrimidin-2(lH)-one; or l-isopropyl-5-methyIpyrimidine-2,4(lH,3H)-dione, R' is - CH2OC(0)R", and R" is -C(CH3)3 or -CH(CH3)2 including pharmaceutically acceptable salts thereof. The present invention also provides a process for preparing a compound of formula (la) and a compound of formula (I) for use in treating a viral infection.

  本发明提供了一种化合物，其化学式为(I)，其中R为9-异丙基-9H-嘌呤-6-胺；2-氨基-9-异丙基-1H-嘌呤-6(9H)-酮；4-氨基-1-异丙基嘧啶-2(1H)-酮；或1-异丙基-5-甲基嘧啶-2,4(1H,3H)-二酮，R'为-CH2OC(0)R"，R"为-C(CH3)3或-CH(CH3)2，包括其药用可接受的盐。本发明还提供了一种制备化学式(la)的化合物和化学式(I)的化合物的方法，用于治疗病毒感染。
• Salts of antiviral phosphonate analogues and process for preparation thereof
  申请人：CIPLA LIMITED

  公开号：US11390637B2

  公开（公告）日：2022-07-19

  The present invention relates to certain acid salts of (((1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methyl)(phenoxy) phosphoryloxy)methyl pivalate of Formula (I), to processes for their preparation; to pharmaceutical compositions comprising such compounds, and methods of treating a disease which responds to inhibition of nucleotide reverse transcriptase activity.

  本发明涉及式(I)的(((1-(6-氨基-9H-嘌呤-9-基)丙-2-氧基)甲基)(苯氧基)磷酰氧基)甲基特戊酸酯的某些酸盐、 制备工艺；包含此类化合物的药物组合物，以及治疗对抑制核苷酸逆转录酶活性有反应的疾病的方法。
• ANTIVIRAL PHOSPHONATE ANALOGUES AND PROCESS FOR PREPARATION THEREOF
  申请人：Cipla Limited

  公开号：EP2912047A1

  公开（公告）日：2015-09-02
• SALTS OF ANTIVIRAL PHOSPHONATE ANALOGUES AND PROCESS FOR PREPARATION THEREOF
  申请人：Cipla Limited

  公开号：EP3595671A1

  公开（公告）日：2020-01-22