[2,4-Dihydroxy-6-methyl-5-(3-methyl-4-methylsulfanyl-2-oxobutyl)oxan-2-yl] formate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: [2,4-Dihydroxy-6-methyl-5-(3-methyl-4-methylsulfanyl-2-oxobutyl)oxan-2-yl] formate
• 英文别名: [2,4-dihydroxy-6-methyl-5-(3-methyl-4-methylsulfanyl-2-oxobutyl)oxan-2-yl] formate
• 化学式: C₁₃H₂₂O₆S
• 分子量: 306.38
• InChiKey: GBZUDYKVFQZLGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Glycopegylated Factor IX
  申请人：NOVO NORDISK A/S

  公开号：US20140112903A1

  公开（公告）日：2014-04-24

  Conjugates between Factor IX and PEG moieties. are disclosed in the present application. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
• US8791070B2
  申请人：——

  公开号：US8791070B2

  公开（公告）日：2014-07-29