2-[1-(phenethylamino)ethyl]-4(3H)-quinazolinone | 143993-21-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-[1-(phenethylamino)ethyl]-4(3H)-quinazolinone
• 英文别名: 2-[1-(2-phenylethylamino)ethyl]-3H-quinazolin-4-one
• CAS: 143993-21-9
• 化学式: C₁₈H₁₉N₃O
• 分子量: 293.368
• InChiKey: IORILOKNTLZJQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  53.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(1-bromoethyl)quinazolin-4(3H)-one 、 2-苯乙胺 以 乙醇 为溶剂， 反应 12.0h， 以68%的产率得到2-[1-(phenethylamino)ethyl]-4(3H)-quinazolinone
  参考文献：
  名称：

  Koekoesi, Jozsef; Almasi, Janos; Podanyi, Benjamin, Heterocycles, 1998, vol. 48, # 9, p. 1851 - 1866

  摘要：

  DOI：

文献信息

• COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK
  申请人：Scripps Health

  公开号：US20210187111A1

  公开（公告）日：2021-06-24

  Described herein are methods and compositions for disrupting a macrophage network. Described herein are targeting agents capable of targeting one or more cells of a macrophage network. Methods for treating various diseases, such as cancer and granulomatous diseases are provided.
• [EN] COMPOSITIONS AND METHODS FOR DISRUPTING A MACROPHAGE NETWORK<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR PERTURBER UN RÉSEAU DE MACROPHAGES
  申请人：SCRIPPS HEALTH

  公开号：WO2020018434A1

  公开（公告）日：2020-01-23

  Described herein are methods and compositions for disrupting a macrophage network. Described herein are targeting agents capable of targeting one or more cells of a macrophage network. Methods for treating various diseases, such as cancer and granulomatous diseases are provided.
• Koekoesi, Jozsef; Almasi, Janos; Podanyi, Benjamin, Heterocycles, 1998, vol. 48, # 9, p. 1851 - 1866
  作者：Koekoesi, Jozsef、Almasi, Janos、Podanyi, Benjamin、Feher, Miklos、Boecskei, Zsolt、et al.

  DOI：——

  日期：——