tert-butyl N-[(3R)-1-[1-[(2,5-difluorophenyl)methyl]-5-methyl-6,9-dioxo-7H-imidazo[1,2-a]purin-2-yl]piperidin-3-yl]carbamate | 1417715-86-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: tert-butyl N-[(3R)-1-[1-[(2,5-difluorophenyl)methyl]-5-methyl-6,9-dioxo-7H-imidazo[1,2-a]purin-2-yl]piperidin-3-yl]carbamate
• CAS: 1417715-86-6
• 化学式: C₂₅H₂₉F₂N₇O₄
• 分子量: 529.547
• InChiKey: OQKLRZBMIZUELX-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• TRICYCLIC HETEROCYCLES USEFUL AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20140113920A1

  公开（公告）日：2014-04-24

  The present invention is directed to novel tricyclic heterocycles of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
• US9051329B2
  申请人：——

  公开号：US9051329B2

  公开（公告）日：2015-06-09