(3aR)-6-methyl-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃类
• 英文名称: (3aR)-6-methyl-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan
• 化学式: C₇H₁₂O₂
• 分子量: 128.17
• InChiKey: HGBAJKXNBQUWSB-YURFNIAASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] FIBERS COMPRISING POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVERY<br/>[FR] FIBRES COMPRENANT DES COPOLYMÈRES DE POLYESTERAMIDE DESTINÉES À L'ADMINISTRATION DE MÉDICAMENTS
  申请人：DSM IP ASSETS BV

  公开号：WO2014064196A1

  公开（公告）日：2014-05-01

  The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (IV), wherein -m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9, -m+p+q=1 whereby m or p could be 0, -n is about 5 to about 300; (pref. 50-200), -R1 is independently selected from the group consisting of (C2-C20) alkylene or (C2-C20) alkenylene and combinations thereof; -R3 and R4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6- C10)aryl, -(CH2)SH, -(CH2)2S(CH 3), -CH2OH, -CH(OH)CH3, -(CH2)4NH3+, --(CH2)3NHC(=NH2+)NH2, -CH2COOH, -(CH2)COOH, -CH2-CO-NH2, -CH2CH2-CO-NH2, -- -CH2CH2COOH, CH3-CH2-CH(CH3)-, (CH3)2-CH-CH2-, H2N-(CH2)4-, Ph-CH2-, CH=C-CH2-, HO-p-Ph-CH2-, (CH3)2-CH-, Ph-NH-, NH-(CH2)3-C-, NH-CH=N-CH=C-CH2-. -R5 is selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy or oligoethyleneglycol, -R6 is selected from bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (III); -R7 is selected from the group consisting of (C6-C10)aryl (C1C6)alkyl, -R8 is -(CH2)4-; whereby a is at least 0.05 and b is at least 0.05 and a+b=1.