3-(3-cyclopropyloxyphenyl)-5-methyl-2-[1-(7H-purin-6-ylamino)ethyl]quinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3-(3-cyclopropyloxyphenyl)-5-methyl-2-[1-(7H-purin-6-ylamino)ethyl]quinazolin-4-one
• 化学式: C₂₅H₂₃N₇O₂
• 分子量: 453.5
• InChiKey: LTCSMYMYNAGAEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYOSITOL 3-KINASE DELTA
  申请人：ICOS CORPORATION

  公开号：US20140121224A1

  公开（公告）日：2014-05-01

  Compounds that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3Kδ plays a role in leukocyte function, using the compounds also are disclosed.

  本发明公开了抑制PI3Kδ活性的化合物，包括选择性抑制PI3Kδ活性的化合物。本发明还公开了通过使用这些化合物来抑制磷脂酰肌醇3-激酶δ亚型（PI3Kδ）活性的方法，以及使用这些化合物治疗疾病的方法，例如免疫和炎症紊乱，其中PI3Kδ在白细胞功能中发挥作用。
• Tert-butyl (s)-(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate precursor of a quinazolinone inhibitor of human phosphatidylinositol 3-kinase delta and a process for preparing thereof
  申请人：ICOS CORPORATION

  公开号：US10906907B2

  公开（公告）日：2021-02-02

  Compounds that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity, are disclosed. Methods of preparing such compounds are also disclosed, including the preparation and use of the compound tert-butyl (S)-(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbamate of formula (110) as a precursor to synthesize an exemplary compound disclosed in this application, (S)-2-(1-((9H-purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3Kδ plays a role in leukocyte function, using the compounds also are disclosed.

  本研究公开了抑制 PI3Kδ 活性的化合物，包括选择性抑制 PI3Kδ 活性的化合物。还公开了制备此类化合物的方法，包括制备和使用式(110)的化合物(S)-(1-(5-氟-4-氧代-3-苯基-3,4-二氢喹唑啉-2-基)丙基)氨基甲酸叔丁酯作为前体合成本申请中公开的示例性化合物(S)-2-(1-((9H-嘌呤-6-基)氨基)丙基)-5-氟-3-苯基喹唑啉-4(3H)-酮。本申请还公开了抑制磷脂酰肌醇 3-激酶δ异构体（PI3Kδ）活性的方法，以及使用这些化合物治疗疾病的方法，例如免疫和炎症紊乱，其中 PI3Kδ 在白细胞功能中起作用。
• US8980901B2
  申请人：——

  公开号：US8980901B2

  公开（公告）日：2015-03-17