4-(2,6-dioxo-7-propyl-3H-purin-8-yl)benzenesulfonic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 4-(2,6-dioxo-7-propyl-3H-purin-8-yl)benzenesulfonic acid
• 化学式: C₁₄H₁₄N₄O₅S
• 分子量: 350.35
• InChiKey: XNLIRGSJPOUBLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  139
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] METHODS FOR TREATMENT OF PRIMARY CANCER AND CANCER METASTASIS<br/>[FR] MÉTHODES DE TRAITEMENT D'UN CANCER PRIMAIRE ET DE LA MÉTASTASE CANCÉREUSE
  申请人：UNIV TEXAS

  公开号：WO2014074529A1

  公开（公告）日：2014-05-15

  Embodiments of the invention are directed to administering a therapeutically effective amount of a purinergic P2 receptor agonist alone or in combination with adenosine receptor antagonist and/or other anti-cancer therapies for the treatment of cancer. Agonist for the P2 receptors include non-hydrolysable ATP analogs. In particular aspects the cancer is a metastatic cancer, such as a bone metastasis.
• [EN] REDUCING DIABETES IN PATIENTS RECEIVING HMG-COA REDUCTASE INHIBITORS (STATINS)<br/>[FR] RÉDUCTION DE DIABÈTE CHEZ DES PATIENTS RECEVANT DES INHIBITEURS DE L'HMG-COA RÉDUCTASE (STATINES)
  申请人：JOLLA INST ALLERGY IMMUNOLOG

  公开号：WO2014153424A1

  公开（公告）日：2014-09-25

  The invention provides compositions, methods and uses for reducing insulin resistance or risk of diabetes in a subject taking a statin. The invention also provides compositions, methods and uses for reducing or decreasing increases in blood glucose caused by a statin in a subject taking a statin. The invention further provides compositions, methods and uses for reducing insulin resistance or risk of diabetes in a subject taking statins, and for treating diabetes in a subject taking statins. The invention moreover provides compositions, including an adenosine receptor antagonist, and/or an A2B receptor antagonist, and/or a CD73 antagonist and a statin.