2-(2-diethylaminoethyl)thiophene | 57582-21-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(2-diethylaminoethyl)thiophene
• 英文别名: 2-(2-Diethylaminoethyl)-thiophen；diethyl-(2-thiophen-2-yl-ethyl)-amine；2-(2-Diethylaminoethyl) thiophene；N,N-diethyl-2-thiophen-2-ylethanamine
• CAS: 57582-21-5
• 化学式: C₁₀H₁₇NS
• 分子量: 183.318
• InChiKey: DYJVRJOIINTYPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  31.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-diethylaminoethyl)thiophene 在 盐酸 、 sodium hydroxide 、 正丁基锂 、 sodium 、 氯化铵 、 氯化苄 作用下， 反应 7.0h， 生成 ethyl ester of 7-diethylamino-s-trans-2(E),4(E)-heptadienoic acid
  参考文献：
  名称：

  Action of alkali metals in liquid ammonia on substituted thiophene derivatives Communication 8. Preparation of dialkylamino-s-trans-2(E),4(E)-alkadienoic acids by reductive splitting of 5-dialkylaminoalkyl-2-thiophenecarboxylic acids

  摘要：

  DOI：

  10.1007/bf00954354

文献信息

• Method for production of halogen-containing phthalocyanine compound
  申请人：Hirota Kouichi

  公开号：US20050203293A1

  公开（公告）日：2005-09-15

  This invention relates to a method for for the production of a halogen-containing phthalocyaline compound by the cyclization of phthalonitrile compounds either singly or in combination with a metal compound, characterized in effecting the cyclization in an organic compound having a hydroxyl group and/or a carboxylic acid in an amount in the range of 0.01-10 mass parts per one mass part of the phthalonitrile compounds while continuing the introduction of an inert gas. This method, by using a solvent capable of serving as a specific oxygen source destined to participate in the reaction of complexing a metal compound introduced into a phthalocyanine dye, permits the production of a phthalocyanine compound inexpensively in a high yield.

  这项发明涉及一种通过在具有羟基和/或羧酸的有机化合物中以每一部分邻苯二腈化合物0.01-10质量部的量的情况下，通过将邻苯二腈化合物单独或与金属化合物组合进行环化来生产含卤素的酞菁化合物的方法，其特征在于在继续引入惰性气体的同时进行环化。通过使用能够作为特定氧源的溶剂来参与将引入到酞菁染料中的金属化合物络合反应的方法，可以以高产率廉价地生产酞菁化合物。
• [EN] PROCESS FOR DEMETHYLATING AROMATIC METHYL ETHERS USING 3 -MERCAPTOPROPIONIC ACID<br/>[FR] PROCÉDÉ DE DÉMÉTHYLATION DES ÉTHERS DE MÉTHYLE AROMATIQUES À L'AIDE D'ACIDE 3-MERCAPTOPROPIONIQUE
  申请人：LEK PHARMACEUTICALS

  公开号：WO2011154152A1

  公开（公告）日：2011-12-15

  The present application discloses a process for demethylating aromatic methyl ethers by reaction with 3 -mercaptopropionic acid or salts thereof. One preferred example is the demethylation of venlafaxine forming 0 - desmethylvenlafaxine.

  本申请公开了一种通过与3-巯基丙酸或其盐反应来去甲基化芳香族甲基醚的方法。一个优选的例子是文拉法辛的去甲基化反应，形成0-去甲基文拉法辛。
• Process for demethylating aromatic methyl ethers using 3-mercaptopropionic acid
  申请人：LEK Pharmaceuticals d.d.

  公开号：EP2394976A1

  公开（公告）日：2011-12-14

  The present application discloses a process for demethylating aromatic methyl ethers by reaction with 3-mercaptopropionic acid or salts thereof. One preferred example is the demethylation of venlafaxine forming O-desmethylvenlafaxine.

  本申请揭示了一种利用3-巯基丙酸或其盐与芳香族甲基醚发生反应进行去甲基化的过程。一个首选的示例是文拉法辛的去甲基化，形成O-去甲基文拉法辛。
• [EN] PROCESS FOR PREPARING O-DESMETHYLVENLAFAXINE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE O-DESMÉTHYLVENLAFAXINE
  申请人：GENERICS UK LTD

  公开号：WO2009053731A1

  公开（公告）日：2009-04-30

  The present invention provides a convenient and efficient process for the preparation of O-desmethylvenlafaxine (ODV), comprising the reaction of venlafaxine, or a salt thereof, with a thiol reagent such as a dithiol, an aminothiol or an inorganic thiol. The present invention also provides a process for purifying ODV base,said process comprising the steps of mixing crude ODV base with an alcohol to form a suspension and adding acid followed by base to generate ODV base with high purity.

  本发明提供了一种方便高效的制备O-去甲基文拉法辛（ODV）的方法，包括将文拉法辛或其盐与硫醇试剂（如二硫醇、氨硫醇或无机硫醇）反应。本发明还提供了一种纯化ODV碱的方法，该方法包括将粗制ODV碱与醇混合形成悬浮液，然后添加酸再加入碱以生成高纯度的ODV碱。
• [EN] COMPOSITIONS AND METHODS FOR DELIVERY OF NUCLEIC ACIDS<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：POSEIDA THERAPEUTICS INC

  公开号：WO2022087148A1

  公开（公告）日：2022-04-28

  The present disclosure provides compositions and methods for the genetic modification of cells, including, but not limited to, resting T-cells and hepatocytes. The compositions and methods can comprise lipid nanoparticles, wherein the lipid nanoparticles comprise at least one multivalent cationic bolaform amphiphilic lipid, at least one structural lipid, at least one phospholipid and at least one PEGylated lipid.

  本公开提供了细胞基因修饰的组合物和方法，包括但不限于静止的T细胞和肝细胞。该组合物和方法可以包括脂质纳米粒子，其中脂质纳米粒子包括至少一种多价阳离子球形两亲性脂质、至少一种结构脂质、至少一种磷脂和至少一种PEG化脂质。