(2R,3S,4R,5R)-4-amino-5-(4-amino-2-methylidenepyrimidin-1-yl)-2-(hydroxymethyl)-4-methyloxolan-3-ol

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: (2R,3S,4R,5R)-4-amino-5-(4-amino-2-methylidenepyrimidin-1-yl)-2-(hydroxymethyl)-4-methyloxolan-3-ol
• 化学式: C₁₁H₁₈N₄O₃
• 分子量: 254.29
• InChiKey: QCQZESCXODXOLR-QCNRFFRDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  117
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• 2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
  申请人：Girijavallabhan Vinay

  公开号：US20140128339A1

  公开（公告）日：2014-05-08

  The present invention relates to 2′-Methyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R 1 , R 2 and R 3 , are as defined herein. The present invention also relates to compositions comprising at least one 2′-Methyl Substituted Nucleoside Derivative, and methods of using the 2′-Methyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.