(3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methyl-2-[4-(methylamino)-2-oxopyrimidin-1-yl]oxolane-3-carbonitrile

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: (3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methyl-2-[4-(methylamino)-2-oxopyrimidin-1-yl]oxolane-3-carbonitrile
• 化学式: C₁₂H₁₆N₄O₄
• 分子量: 280.28
• InChiKey: MNIJDCODNUGHIC-YBYPLNBPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• 2'-CYANO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2696679B1

  公开（公告）日：2017-08-02
• 2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
  申请人：Girijavallabhan Vinay

  公开号：US20140128339A1

  公开（公告）日：2014-05-08

  The present invention relates to 2′-Methyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R 1 , R 2 and R 3 , are as defined herein. The present invention also relates to compositions comprising at least one 2′-Methyl Substituted Nucleoside Derivative, and methods of using the 2′-Methyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.