[(1S,2R,3S,5R,6S,16E,18E,21S)-11-chloro-7-decyl-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[acetyl(methyl)amino]propanoate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: [(1S,2R,3S,5R,6S,16E,18E,21S)-11-chloro-7-decyl-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[acetyl(methyl)amino]propanoate
• 化学式: C₄₄H₆₆ClN₃O₁₀
• 分子量: 832.5
• InChiKey: YADIYIFTDVBYDI-APFGWRPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  58
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  157
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• HYDRAZINYL-INDOLE COMPOUNDS AND CONJUGATES
  申请人：Redwood Bioscience, Inc.

  公开号：EP2920167A1

  公开（公告）日：2015-09-23
• [EN] HYDRAZINYL-INDOLE COMPOUNDS AND CONJUGATES<br/>[FR] COMPOSÉS HYDRAZINYL-INDOLES ET CONJUGUÉS
  申请人：REDWOOD BIOSCIENCE INC

  公开号：WO2014078566A1

  公开（公告）日：2014-05-22

  The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.
• [EN] ANTI-UPAR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF<br/>[FR] CONJUGUÉS D'ANTICORPS-MÉDICAMENT ANTI-UPAR ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2019113248A1

  公开（公告）日：2019-06-13

  The present disclosure relates to antibody-drug conjugates ("ADCs") that bind to and modulate the activity of urokinase plasminogen activator receptor (uPAR/CD87), compositions comprising the agents, and methods involving use of the compositions.