(3S)-1-phenylhexan-3-amine | 1207873-41-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (3S)-1-phenylhexan-3-amine
• CAS: 1207873-41-3
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: VPRXVPWWCRIOJJ-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-(1,3-benzoxazol-2-yl)-2-[(3R)-1-phenylhex-5-en-3-yl]hydrazine 在 盐酸 、 氢气 、 palladium(II) hydroxide 作用下， 以 乙醇 、 水 为溶剂， 60.0 ℃ 、827.39 kPa 条件下， 以90%的产率得到(3S)-1-phenylhexan-3-amine
  参考文献：
  名称：

  Asymmetric Allylation, Crotylation, and Cinnamylation of N-Heteroaryl Hydrazones

  摘要：

  A new class of N-heteroaryl hydrazones has been developed as an alternative to N-acylhydrazones and 2-aminophenol-derived imines in asymmetric allylation, crotylation, and cinnamylation reactions with chiral allylchlorosilanes. The hydrazones are readily and inexpensively prepared, perform well in the allylation chemistry, and more importantly, the product hydrazides may be smoothly reduced by Pd(OH)(2)-catalyzed hydrogenation to reveal the corresponding amine products.

  DOI：

  10.1021/ol9026864

文献信息

• Asymmetric Allylation, Crotylation, and Cinnamylation of <i>N</i>-Heteroaryl Hydrazones
  作者：Miriam Inbar Feske、Alexander Buitrago Santanilla、James L. Leighton

  DOI：10.1021/ol9026864

  日期：2010.2.19

  A new class of N-heteroaryl hydrazones has been developed as an alternative to N-acylhydrazones and 2-aminophenol-derived imines in asymmetric allylation, crotylation, and cinnamylation reactions with chiral allylchlorosilanes. The hydrazones are readily and inexpensively prepared, perform well in the allylation chemistry, and more importantly, the product hydrazides may be smoothly reduced by Pd(OH)(2)-catalyzed hydrogenation to reveal the corresponding amine products.