propan-2-yl (2R)-2-[[[(2R,3R,4R,5R)-4-fluoro-3-hydroxy-4-methyl-5-(2-methylidene-4-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: propan-2-yl (2R)-2-[[[(2R,3R,4R,5R)-4-fluoro-3-hydroxy-4-methyl-5-(2-methylidene-4-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
• 化学式: C₂₃H₃₁FN₃O₈P
• 分子量: 527.5
• InChiKey: XVZMSCXWTZLRPS-NZDDJAGTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• D-Alanine Ester of Rp-Nucleoside Analog
  申请人：Idenix Pharmaceuticals, Inc.

  公开号：US20140140951A1

  公开（公告）日：2014-05-22

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, provided herein is an isolated compound according to Formula Ia: or a pharmaceutically acceptable salt or solvate thereof.
• PROCESS FOR MAKING PHOSPHORAMIDATE PROTECTED NUCLEOSIDE COMPOUNDS
  申请人：SILVERMAN Steven M.

  公开号：US20180111954A1

  公开（公告）日：2018-04-26

  The present invention is directed to process for making Compounds of Formula (II): (II), and salts thereof, wherein B, X, R 2 , R 3 , R 4 R 7 , R 8 and R 9 are defined herein.