4-amino-1-[(3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 4-amino-1-[(3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one
• 化学式: C₁₀H₁₅N₃O₄
• 分子量: 241.24
• InChiKey: DYPDKNUWDNOWPU-PIWGOKLLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• MIXTURE OF RP/SP GEMCITABINE-[PHENYL-(BENZYLOXY-L-ALANINYL)]-PHOSPHATE
  申请人：University College Cardiff Consultants Limited

  公开号：EP3150616A1

  公开（公告）日：2017-04-05

  A process for preparing phosphoramidates of nucleosides where a desired enantiomer, having regard to the asymmetric chiral centre of the phosphorus atom P, is provided in an enriched amount. The process comprises admixing a nucleoside with a phosphorochloridate in the presence of a catalyst comprising a metal salt selected from the group consisting of salts of Ciu Fe, La and Yb.

  一种制备核苷磷酰胺酸盐的工艺，在该工艺中，根据磷原子 P 的不对称手性中心，可提供所需的对映体，且对映体的含量较高。该工艺包括在催化剂存在下将核苷与氯代磷酰胺混合，催化剂由选自 Ciu Fe、La 和 Yb 盐组成的金属盐构成。
• [EN] PROCESS FOR PREPARING NUCLEOSIDE PRODRUGS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE PROMÉDICAMENTS À BASE DE NUCLÉOSIDES
  申请人：UNIV CARDIFF

  公开号：WO2014076490A1

  公开（公告）日：2014-05-22

  A process for preparing phosphoramidates of nucleosides where a desired enantiomer, having regard to the asymmetric chiral centre of the phosphorus atom P, is provided in an enriched amount. The process comprises admixing a nucleoside with a phosphorochloridate in the presence of a catalyst comprising a metal salt selected from the group consisting of salts of Ciu Fe, La and Yb.