(12S)-4,10-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-18,23-dioxa-7,11,31-triazatetracyclo[22.2.2.214,17.15,9]hentriaconta-1(27),5,7,9(31),14,16,24(28),25,29-nonaene-12-carboxamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: (12S)-4,10-dioxo-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-18,23-dioxa-7,11,31-triazatetracyclo[22.2.2.214,17.15,9]hentriaconta-1(27),5,7,9(31),14,16,24(28),25,29-nonaene-12-carboxamide
• 化学式: C₃₆H₃₆N₄O₆
• 分子量: 620.7
• InChiKey: SSIPGENUZXOSKP-IZEXYCQBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  46
• 可旋转键数：
  5
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] MACROCYCLIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS MACROCYCLIQUES ET LEURS UTILISATIONS
  申请人：ADELAIDE RES & INNOVATION PTY

  公开号：WO2014075146A1

  公开（公告）日：2014-05-22

  The present invention relates to novel macrocyclic compounds of Formula I and their use as novel therapeutic agents for example as novel compounds used in methods of preventing and/or treating a disease, condition or state in a subject associated with dysregulation of protease activity and/or dysregulation of proteosome activity

  本发明涉及公式I的新型大环化合物及其作为新型治疗剂的用途，例如作为用于预防和/或治疗与蛋白酶活性失调和/或蛋白酶体活性失调相关的疾病、病况或状态的新型化合物的方法中使用。
• MACROCYCLIC COMPOUNDS AND USES THEREOF
  申请人：ADELAIDE RESEARCH & INNOVATION PTY LTD

  公开号：US20150299250A1

  公开（公告）日：2015-10-22

  The present invention relates to novel macrocyclic compounds of Formula I and their use as novel therapeutic agents for example as novel compounds used in methods of preventing and/or treating a disease, condition or state in a subject associated with dysregulation of protease activity and/or dysregulation of proteosome activity

  本发明涉及一种新型的大环化合物I及其作为新型治疗剂的用途，例如作为新型化合物用于预防和/或治疗与蛋白酶活性和/或蛋白酶体活性失调有关的主体的疾病、病况或状态的方法。