5-ethynyl-1-[(2R,4R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-ethynyl-1-[(2R,4R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• 化学式: C₁₁H₁₂N₂O₅
• 分子量: 252.22
• InChiKey: CDEURGJCGCHYFH-PSGOWDBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  99.1
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] HEAVY ATOM LABELED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACID POLYMERS, AND USES THEREOF<br/>[FR] NUCLÉOSIDES, NUCLÉOTIDES ET POLYMÈRES D'ACIDES NUCLÉIQUES MARQUÉS AVEC DES ATOMES LOURDS ET LEURS UTILISATIONS
  申请人：ZS GENETICS INC

  公开号：WO2014078652A1

  公开（公告）日：2014-05-22

  The present disclosure provides compositions and methods to sequence nucleic acid polymers for improving sequencing read length using electron microscopy, e.g., high-resolution scanning transmission electron microscopy (STEM). The present disclosure further provides heavy-atom labeled compounds of Formula (I): nucleic acid polymers comprising one or more heavy-atom labeled units of Formula (II'): such as heavy-atom labeled nucleic acid polymers of Formula (II): and salts thereof, wherein each of G 1, G2, G 3, M 1, M2, Base, and n are as defined herein, optionally for use in the methods described.

  本公开提供了一种通过电子显微镜（例如高分辨扫描透射电子显微镜（STEM））对核酸聚合物进行测序以改善测序读长的组合物和方法。本公开进一步提供了式（I）的重原子标记化合物：包括一个或多个式（II'）的重原子标记单元的核酸聚合物，例如式（II）的重原子标记核酸聚合物，以及其盐，其中G1、G2、G3、M1、M2、碱基（Base）和n的每个定义如本文所述，可选择用于所述方法中。
• DEVICES, COMPOSITIONS AND METHODS FOR IMAGING WITH RAMAN SCATTERING
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20200200763A1

  公开（公告）日：2020-06-25

  Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.
• DEVICES, COMPOSITIONS AND METHODS FOR IMAGING WITH RAMAN SCATTERING AND FOR SUPER-MULTIPLEX VIBRATIONAL IMAGING
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20210068663A1

  公开（公告）日：2021-03-11

  Exemplary methods, systems and computer-accessible medium for detecting at least one condition of at least one disease. In particular, it is possible to administer at least one composition to at least one patient, where the at least one composition includes at least one bond-edited compound configured to target at least one of a disease tissue or a pathogen. Further, it is possible to receive information related to the administration of the composition to the patient. It is also possible to detect the at least one bond-edited compound using a Raman scattering arrangement.