N,N-Diisopropyl-2-ethylbutylamine | 200342-33-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-Diisopropyl-2-ethylbutylamine
• 英文别名: 2-ethyl-N,N-di(propan-2-yl)butan-1-amine
• CAS: 200342-33-2
• 化学式: C₁₂H₂₇N
• mdl: MFCD00467770
• 分子量: 185.35
• InChiKey: SUBFZYQWYBUTGO-UHFFFAOYSA-N

物化性质

• 沸点：
  191.8±8.0 °C(Predicted)
• 密度：
  0.792 g/mL at 20 °C(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• PREPARATION OF NORMORPHINANS
  申请人：Mallinckrodt LLC

  公开号：US20150141649A1

  公开（公告）日：2015-05-21

  The present invention provides processes for preparing normorphinans from N-substituted morphinans. In particular, the invention provides methods for removing the N-substituent from the N-substituted morphinan to from a normorphinan carbamate, and then removing the carbamate functionality from the normorphinan carbamate to form the normorphinan.

  本发明提供了从N-取代吗啡内酯制备正吗啡内酯的方法。具体而言，本发明提供了从N-取代吗啡内酯中去除N-取代基，形成正吗啡内酯羰酸酯的方法，然后去除正吗啡内酯羰酸酯中的羰酸酯功能团，形成正吗啡内酯的方法。
• Process for preparing 3-isochromanone
  申请人：——

  公开号：US20020143193A1

  公开（公告）日：2002-10-03

  A process for the preparation of 3-isochromanone which comprises contacting an o-xylene-&agr;,&agr;′-dihalide with carbon monoxide, in the presence of a catalyst and a hindered amine base in a liquid medium comprising water and a tertiary alcohol.

  一种制备3-异色香酮的方法，包括在液体介质中将邻二卤代甲苯与一氧化碳在催化剂和受阻胺碱存在下接触，所述液体介质包括水和三级醇。
• PROCESS FOR PREPARING SAFINAMIDE
  申请人：MEDICHEM, S.A.

  公开号：US20210040033A1

  公开（公告）日：2021-02-11

  The present invention is related to a process for preparing safinamide and salts thereof, preferably safinamide methanesulfonate, with high yields and high enantiomeric and chemical purity without the need of using highly pure intermediates. The process of the present invention is suitable for the production of safinamide and its salts, preferably safinamide methanesulfonate, at industrial scale.

  本发明涉及一种制备沙非胺及其盐的方法，优选为甲磺酸盐沙非胺，具有高产率、高对映体和化学纯度，无需使用高纯度中间体。本发明的方法适用于在工业规模上生产沙非胺及其盐，优选为甲磺酸盐沙非胺。
• BILE ACID DERIVATIVES AND METHODS FOR SYNTHESIS AND USE
  申请人：City of Hope

  公开号：US20170233431A1

  公开（公告）日：2017-08-17

  Provided herein, inter alia, are methods for the preparation of modulators of farnesoid X receptor (FXR), and compositions and uses of the modulators of FXR.

  本文提供了调节法尼索醇X受体（FXR）的方法，以及FXR调节剂的组成和用途。
• MIMETIC COMPOSITIONS AND THE PRODUCTION THEREOF
  申请人：McLaughlin Mark L.

  公开号：US20100216992A1

  公开（公告）日：2010-08-26

  The present invention generally relates to compositions including six membered heterocyclic 1,4-diaza-2-one moieties covalently bonded by a hydrazine bond and processes for producing the same. The compositions of the present invention may be utilized as peptido- and/or proteomimetics, for example,' in connection with alpha-helical proteins, like Bcl-2 proteins.

  本发明通常涉及包括由肼键共价结合的六元杂环1,4-二氮杂-2-酮基团的组合物及其制备方法。本发明的组合物可以用作肽类和/或蛋白质类似物，例如，与α-螺旋蛋白质（如Bcl-2蛋白质）相关联。