2-[4-Amino-6-(3-hydroxyprop-1-ynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-(ethoxymethyl)oxolane-3,4-diol

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 吡咯并嘧啶核苷和核苷酸
• 英文名称: 2-[4-Amino-6-(3-hydroxyprop-1-ynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-(ethoxymethyl)oxolane-3,4-diol
• 英文别名: 2-[4-amino-6-(3-hydroxyprop-1-ynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-(ethoxymethyl)oxolane-3,4-diol
• 化学式: C₁₆H₂₀N₄O₅
• 分子量: 348.35
• InChiKey: ZTTXMKWAWAHLHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Alternative nucleic acid molecules and uses thereof
  申请人：Moderna Therapeutics, Inc.

  公开号：EP2918275B1

  公开（公告）日：2016-05-18
• MODIFIED POLYNUCLEOTIDES FOR TREATING PROTEIN DEFICIENCY
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140148502A1

  公开（公告）日：2014-05-29

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES ENCODING V-MYC AVIAN MYELOCYTOMATOSIS VIRAL ONCOGENE HOMOLOG
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140193482A1

  公开（公告）日：2014-07-10

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• HETEROLOGOUS UNTRANSLATED REGIONS FOR MRNA
  申请人：ModernaTX, Inc.

  公开号：US20170252461A1

  公开（公告）日：2017-09-07

  The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
• IN VIVO PRODUCTION OF PROTEINS
  申请人：ModernaTX, Inc.

  公开号：US20170348436A1

  公开（公告）日：2017-12-07

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.