2-Ethyl-4,7-dimethyl-6-[4-(triiodomethyl)phenyl]purino[7,8-a]imidazole-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-Ethyl-4,7-dimethyl-6-[4-(triiodomethyl)phenyl]purino[7,8-a]imidazole-1,3-dione
• 英文别名: 2-ethyl-4,7-dimethyl-6-[4-(triiodomethyl)phenyl]purino[7,8-a]imidazole-1,3-dione
• 化学式: C₁₈H₁₆I₃N₅O₂
• 分子量: 715.1
• InChiKey: VKZAGAWAORYFIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] Small Molecule Bicyclic and Tricyclic CFTR Correctors<br/>[FR] CORRECTEURS DE CFTR BICYCLIQUES ET TRICYCLIQUES À PETITES MOLÉCULES
  申请人：DISCOVERYBIOMED INC

  公开号：WO2014081821A2

  公开（公告）日：2014-05-30

  Novel CFTR corrector compounds that are effective in rescuing halide efflux, delF508-CFTR protein processing, and apical functional chloride ion transport in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of rescuing halide efflux in a cell, correcting a processing defect of a delF508-CFTR protein in a cell, and correcting functional delF508-CFTR chloride channels in a cell are also provided.