N-[4-(diaminomethylideneamino)-5,6-difluoro-6-formyl-2-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-3-yl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: N-[4-(diaminomethylideneamino)-5,6-difluoro-6-formyl-2-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-3-yl]acetamide
• 化学式: C₁₂H₂₀F₂N₄O₆
• 分子量: 354.31
• InChiKey: YQVHALGUEAWJQK-PMWJKDKASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  181
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• 3' Equatorial-Fluorine-Substituted Neuraminidase Inhibitor Compounds, Compositions and Methods for the Use Thereof as Anti-Virals
  申请人：THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：US20170165223A1

  公开（公告）日：2017-06-15

  Equatorial 2,3-fluorinated glycosides compounds of formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza, the methods for their preparation, and their pharmaceutical compositions. The therapeutic effect is achieved via inhibition of viral neuraminidases.
• [EN] 3' EQUATORIAL-FLUORINE-SUBSTITUTED NEURAMINIDASE INHIBITOR COMPOUNDS, COMPOSITIONS AND METHODS FOR THE USE THEREOF AS ANTI-VIRALS<br/>[FR] COMPOSÉS INHIBITEURS DE LA NEURAMINIDASE SUBSTITUÉS PAR LE FLUOR 3' ÉQUATORIAL, COMPOSITIONS ET MÉTHODES
  申请人：UNIV BRITISH COLUMBIA

  公开号：WO2013106937A9

  公开（公告）日：2014-05-30

  [EN] Equatorial 2,3-fluorinated glycosides compounds of formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza, the methods for their preparation, and their pharmaceutical compositions. The therapeutic effect is achieved via inhibition of viral neuraminidases. (Formula (I))
  [FR] L'invention concerne des composés de glucosides du fluor 2,3 équatorial représentés par la formule (I) utilisés pour traiter ou prévenir une infection virale, en particulier la grippe virale, leurs procédés de préparation et leurs compositions pharmaceutiques. L'effet thérapeutique est obtenu par inhibition des neuraminidases virales. (Formula (I).