3-amino-4-[3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,6-dioxopyrimidin-1-yl]butanoic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 3-amino-4-[3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,6-dioxopyrimidin-1-yl]butanoic acid
• 化学式: C₁₃H₁₉N₃O₈
• 分子量: 345.31
• InChiKey: DCIBLPAYWLZXJC-XYBYKAALSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  174
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• MODIFIED GLUCOSIDASE, BETA, ACID POLYNUCLEOTIDES FOR TREATING PROTEIN DEFICIENCY
  申请人：Moderna Threrapeutics, Inc.

  公开号：US20140155473A1

  公开（公告）日：2014-06-05

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• GAMMA-AMINOBUTYRIC ACID A RECEPTOR SUBUNIT BIOMARKERS
  申请人：Regents of the University of Minnesota

  公开号：US20150160241A1

  公开（公告）日：2015-06-11

  The invention provides physical diagnostic tests for schizophrenia, bipolar disorder, major depression, and autism.
• CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING BETA HEMOGLOBINOPATHIES
  申请人：EDITAS MEDICINE, INC.

  公开号：US20200255857A1

  公开（公告）日：2020-08-13

  CRISPR/CAS-related compositions and methods for treatment of beta hemoglobinopathies are disclosed.