2-[(1R,11S,13S,14R)-7-amino-13,14-dihydroxy-15-oxa-2,4,6,9-tetrazatetracyclo[10.2.1.02,10.03,8]pentadeca-3,5,7,9-tetraen-11-yl]butan-2-yloxy-(2-hydroxybutan-2-yl)phosphinic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-[(1R,11S,13S,14R)-7-amino-13,14-dihydroxy-15-oxa-2,4,6,9-tetrazatetracyclo[10.2.1.02,10.03,8]pentadeca-3,5,7,9-tetraen-11-yl]butan-2-yloxy-(2-hydroxybutan-2-yl)phosphinic acid
• 化学式: C₁₈H₂₈N₅O₇P
• 分子量: 457.4
• InChiKey: HDEFQPRDYJGXFA-HTTHLMAISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  186
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• MODIFIED POLYNUCLEOTIDES FOR TREATING ARGININOSUCCINATE SYNTHASE 1 PROTEIN DEFICIENCY
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140155472A1

  公开（公告）日：2014-06-05

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• METHODS OF INCREASING THE VIABILITY OR LONGEVITY OF AN ORGAN OR ORGAN EXPLANT
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20150051268A1

  公开（公告）日：2015-02-19

  The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules for their use in improving organ viability and/or longevity.
• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160199513A1

  公开（公告）日：2016-07-14

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.