[1-[(1R,2R)-1-[2-amino-6-(methylamino)purin-9-yl]-2,3-dihydroxypropoxy]-3-methylpentan-3-yl]oxy-(2-hydroxypropan-2-yl)phosphinic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: [1-[(1R,2R)-1-[2-amino-6-(methylamino)purin-9-yl]-2,3-dihydroxypropoxy]-3-methylpentan-3-yl]oxy-(2-hydroxypropan-2-yl)phosphinic acid
• 化学式: C₁₈H₃₃N₆O₇P
• 分子量: 476.5
• InChiKey: UBGYEZJIMSVWJU-RNVQDCOHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  32
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  198
• 氢给体数：
  6
• 氢受体数：
  12

文献信息

• MODIFIED POLYNUCLEOTIDES FOR TREATING CYSTIC FIBROSIS
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140155474A1

  公开（公告）日：2014-06-05

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR TREATING LIPASE A, LYSOSOMAL ACID, CHOLESTEROL ESTERASE PROTEIN DEFICIENCY
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140155475A1

  公开（公告）日：2014-06-05

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20160304552A1

  公开（公告）日：2016-10-20

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.