8-bromo-4-phenylimidazo[1,5-a]quinoxaline | 1360871-18-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 8-bromo-4-phenylimidazo[1,5-a]quinoxaline
• CAS: 1360871-18-6
• 化学式: C₁₆H₁₀BrN₃
• 分子量: 324.18
• InChiKey: OJVRTLOTCYQCCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基-4-溴苯基氨基甲酸叔丁酯 、 苯基丙醇水合物 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 生成 8-bromo-4-phenylimidazo[1,5-a]quinoxaline
  参考文献：
  名称：

  Straightforward Assembly of Phenylimidazoquinoxalines via a One-Pot Two-Step MCR Process

  摘要：

  An efficient multicomponent-based methodology providing a new entry into a medicinally important complex heterocyclic core is presented. The strategy is very general and able to endow target compounds with the highest possible number of diversity points. Notably, four new chemical bonds and two aromatic rings are formed in a one-pot fashion.

  DOI：

  10.1021/ol3003282

文献信息

• Straightforward Assembly of Phenylimidazoquinoxalines via a One-Pot Two-Step MCR Process
  作者：Fabio De Moliner、Christopher Hulme

  DOI：10.1021/ol3003282

  日期：2012.3.2

  An efficient multicomponent-based methodology providing a new entry into a medicinally important complex heterocyclic core is presented. The strategy is very general and able to endow target compounds with the highest possible number of diversity points. Notably, four new chemical bonds and two aromatic rings are formed in a one-pot fashion.