2-(3-Bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-4-thiazolidinone | 388604-55-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(3-Bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-4-thiazolidinone
• 英文别名: 2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
• CAS: 388604-55-5
• 化学式: C₁₅H₁₁BrClNO₂S
• 分子量: 384.7
• InChiKey: KEGQNJITMFBVAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Treatment of otitis media
  申请人：Research Institute at Nationwide Children's Hospital

  公开号：US10000577B2

  公开（公告）日：2018-06-19

  A method of treating otitis media in a subject is described that includes administering to the subject a therapeutically effective amount of an Actin-Related Protein 2/3 Complex (Arp2/3) inhibitor. The role of Arp2/3 in otitis media was identified using comprehensive proteomic and metabolomic studies of otitis media using the chinchilla model.

  本文描述了一种治疗中耳炎的方法，包括向受试者施用治疗有效量的肌动蛋白相关蛋白 2/3 复合物（Arp2/3）抑制剂。通过使用龙猫模型对中耳炎进行全面的蛋白质组学和代谢组学研究，确定了 Arp2/3 在中耳炎中的作用。
• TREATMENT OF OTITIS MEDIA
  申请人：Research Institute at Nationwid Children's Hospita

  公开号：US20170275379A1

  公开（公告）日：2017-09-28

  A method of treating otitis media in a subject is described that includes administering to the subject a therapeutically effective amount of an Actin-Related Protein 2/3 Complex (Arp2/3) inhibitor. The role of Arp2/3 in otitis media was identified using comprehensive proteomic and metabolomic studies of otitis media using the chinchilla model.