2-cyclopentyl-7H-purin-6-amine;methanesulfonic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-cyclopentyl-7H-purin-6-amine;methanesulfonic acid
• 化学式: C11H17N5O3S
• 分子量: 299.35
• InChiKey: IMXOLIAAACSHQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  143
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Methods for diagnosing and treating prostate cancer
  申请人：Cornell University

  公开号：US10568869B2

  公开（公告）日：2020-02-25

  The invention is directed to a method of inhibiting prostate cancer cell proliferation using a substance that inhibits the activity of a soluble adenylyl cyclase (sAC) protein. The invention also is directed to methods of diagnosing and prognosticating prostate cancer in a subject by evaluating sAC gene or protein expression in the subject.

  本发明涉及一种利用抑制可溶性腺苷酸环化酶（sAC）蛋白活性的物质抑制前列腺癌细胞增殖的方法。本发明还涉及通过评估受试者体内 sAC 基因或蛋白的表达来诊断和预后前列腺癌的方法。
• METHODS FOR DIAGNOSING AND TREATING PROSTATE CANCER
  申请人：Cornell University

  公开号：EP2932273A1

  公开（公告）日：2015-10-21
• INHIBITORS OF SOLUBLE ADENYLYL CYCLASE FOR USE IN THE TREATMENT OF PROSTATE CANCER
  申请人：Cornell University

  公开号：EP2932273B1

  公开（公告）日：2018-03-21
• [EN] METHODS FOR DIAGNOSING AND TREATING PROSTATE CANCER<br/>[FR] MÉTHODES DE DIAGNOSTIC ET DE TRAITEMENT DU CANCER DE LA PROSTATE
  申请人：UNIV CORNELL

  公开号：WO2014093460A1

  公开（公告）日：2014-06-19

  The invention is directed to a method of inhibiting prostate cancer cell proliferation using a substance that inhibits the activity of a soluble adenylyl cyclase (sAC) protein. The invention also is directed to methods of diagnosing and prognosticating prostate cancer in a subject by evaluating sAC gene or protein expression in the subject.