(5S)-5-methyl-3a,4,5,7-tetrahydro-3H-pyrano[3,4-c][1,2]oxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (5S)-5-methyl-3a,4,5,7-tetrahydro-3H-pyrano[3,4-c][1,2]oxazole
• 化学式: C₇H₁₁NO₂
• 分子量: 141.17
• InChiKey: MLDQZNZAPTVQQU-ZBHICJROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  30.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] TETRAHYDROPYRANO[3,4-D][1,3]OXAZIN DERIVATIVES AND THEIR USE AS BACE INHIBITORS<br/>[FR] DÉRIVÉS DE TÉTRAHYDROPYRANO[3,4-D] [1,3]OXAZINE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE BACE
  申请人：PFIZER

  公开号：WO2017051303A1

  公开（公告）日：2017-03-30

  The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula (I), wherein the variables R1, R2, R3, R4 and X are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

  本发明涉及所披露的化合物、互变异构体和该化合物的药学上可接受的盐，其中该化合物具有公式（I）的结构，其中变量R1、R2、R3、R4和X如规范中定义。还披露了相应的药物组合物、治疗方法、合成方法和中间体。
• HEXAHYDROPYRANO [3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS AS INHIBITORS OF BACE1
  申请人：Pfizer Inc.

  公开号：EP2931731A1

  公开（公告）日：2015-10-21
• [EN] HEXAHYDROPYRANO [3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS AS INHIBITORS OF BACE1<br/>[FR] COMPOSÉS D'HEXAHYDROPYRANO [3,4-D][1,3]THIAZIN-2-AMINE EN TANT QU'INHIBITEURS DE BACE1
  申请人：PFIZER

  公开号：WO2014091352A1

  公开（公告）日：2014-06-19

  The present invention provides compounds of Formula (I), and the tautomers thereof, and the pharmaceutically acceptable salts of the compounds and tautomers, wherein the compounds have the structure (I) wherein the variables R1, R2, R3, R4 and x are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.