Tert-butyl 3-(2,2-dimethylpropyl)azetidine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 英文名称: Tert-butyl 3-(2,2-dimethylpropyl)azetidine-1-carboxylate
• 英文别名: tert-butyl 3-(2,2-dimethylpropyl)azetidine-1-carboxylate
• 化学式: C₁₃H₂₅NO₂
• 分子量: 227.34
• InChiKey: WUXKLAFOSFIKEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• CHROMAN DERIVATIVES AS TRPM8 INHIBITORS
  申请人：AMGEN INC.

  公开号：US20150031668A1

  公开（公告）日：2015-01-29

  Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

  公式I的铬化合物和衍生物是TRPM8的有用抑制剂。这些化合物可用于治疗许多TRPM8介导的疾病和情况，并可用于制备用于治疗这些疾病和情况的药物和制剂。这些疾病的例子包括但不限于偏头痛和神经病性疼痛。公式I的化合物具有以下结构：其中变量的定义在此提供。
• TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS
  申请人：AMGEN INC.

  公开号：US20140171639A1

  公开（公告）日：2014-06-19

  Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

  式I的化合物可作为TRPM8的拮抗剂。这些化合物可用于治疗许多TRPM8介导的疾病和病况，并可用于制备用于治疗这些疾病和病况的药物和制剂。这些疾病的例子包括但不限于偏头痛和神经病性疼痛。式I的化合物具有以下结构：其中变量的定义在此提供。
• MYST FAMILY HISTONE ACETYLTRANSFERASE INHIBITORS
  申请人：Epizyme, Inc.

  公开号：US20220162197A1

  公开（公告）日：2022-05-26

  The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
• US9096527B2
  申请人：——

  公开号：US9096527B2

  公开（公告）日：2015-08-04