2,2'-bis-diethylamino-7,7'-dimethoxy-3,3'-methanediyl-bis-chromen-4-one | 153528-59-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,2'-bis-diethylamino-7,7'-dimethoxy-3,3'-methanediyl-bis-chromen-4-one
• 英文别名: 2-(Diethylamino)-3-[[2-(diethylamino)-7-methoxy-4-oxochromen-3-yl]methyl]-7-methoxychromen-4-one
• CAS: 153528-59-7
• 化学式: C₂₉H₃₄N₂O₆
• 分子量: 506.599
• InChiKey: ZAVYYGCNSJWQRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  77.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2,2'-bis-diethylamino-7,7'-dimethoxy-3,3'-methanediyl-bis-chromen-4-one 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以55.7%的产率得到4,4'-methylenbis<3-(diethylamino)-5-(2-hydroxy-4-methoxyphenyl)isoxazole>
  参考文献：
  名称：

  Synthesis of new 3,5-disubstituted isoxazoles with specific anti-group B rhinovirus activity in vitro

  摘要：

  3,5-Disubstituted isoxazoles 4a-f were synthesized as potential anti-rhinovirus agents. These compounds were prepared in good yield by treatment of the corresponding 2-(dialkylamino)chromones 3a-f with hydroxylamine. Compounds 4 were demethylated to obtain dihydroxyderivatives 5, which were then transformed in acetyl-6 and alkylderivatives 7. The methylenbisderivatives 9 were obtained by reaction of bischromones 8 with hydroxylamine. Most compounds were subjected to antiviral screening. Compounds 4c, 7a, 7b and 7c were found to be specific inhibitors of group B rhinoviruses.

  DOI：

  10.1016/0223-5234(93)90025-a
• 作为产物：
  描述：

  2-(diethylamino)-3-morpholinomethyl-7-methoxychromone 、 3-(diethylamino)-1H-naphtho[2,1-b]pyran-1-one 在 乙酸酐 作用下， 反应 1.5h， 以52%的产率得到2-[2'-(diethylamino)-7'-methoxychromon-3'-yl]methyl-3-(diethylamino)-1H-naphtho[2,1-b]pyran-1-one
  参考文献：
  名称：

  由曼尼希碱合成苯并吡喃-4-酮的不对称亚甲基衍生物

  摘要：

  研究了由其曼尼希碱形成的苯并吡喃-4-酮的亚甲基双衍生物。基于这些理由，已经通过使苯并吡喃-4-酮的曼尼希碱与缺乏二烷基氨基甲基的结构相关化合物反应来合成不对称的亚甲基衍生物。

  DOI：

  10.1002/jhet.5570380232

文献信息

• Synthesis of new 3,5-disubstituted isoxazoles with specific anti-group B rhinovirus activity in vitro
  作者：M Mazzei、A Balbi、E Sottofattori、R Garzoglio、A De Montis、S Corrias、P La Colla

  DOI：10.1016/0223-5234(93)90025-a

  日期：1993.1

  3,5-Disubstituted isoxazoles 4a-f were synthesized as potential anti-rhinovirus agents. These compounds were prepared in good yield by treatment of the corresponding 2-(dialkylamino)chromones 3a-f with hydroxylamine. Compounds 4 were demethylated to obtain dihydroxyderivatives 5, which were then transformed in acetyl-6 and alkylderivatives 7. The methylenbisderivatives 9 were obtained by reaction of bischromones 8 with hydroxylamine. Most compounds were subjected to antiviral screening. Compounds 4c, 7a, 7b and 7c were found to be specific inhibitors of group B rhinoviruses.
• Synthesis of unsymmetrical methylene derivatives of benzopyran-4-ones from mannich bases
  作者：Mauro Mazzei、Ramona Dondero、Alessandro Balbi、Gian Maria Bonora

  DOI：10.1002/jhet.5570380232

  日期：2001.3

  The formation of methylene-bis derivatives of benzopyran-4-ones from their Mannich bases was studied. On these grounds, unsymmetrical methylene derivatives have been synthesized by reacting Mannich bases of benzopyran-4-ones with structurally related compounds lacking the dialkylaminomethyl group.

  研究了由其曼尼希碱形成的苯并吡喃-4-酮的亚甲基双衍生物。基于这些理由，已经通过使苯并吡喃-4-酮的曼尼希碱与缺乏二烷基氨基甲基的结构相关化合物反应来合成不对称的亚甲基衍生物。