2-[2-(Oxan-2-yl)propan-2-yl]oxane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2-[2-(Oxan-2-yl)propan-2-yl]oxane
• 英文别名: 2-[2-(oxan-2-yl)propan-2-yl]oxane
• 化学式: C₁₃H₂₄O₂
• 分子量: 212.33
• InChiKey: VOUQXSHAYVRXTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Process for producing a Ziegler Natta procatalyst for ethylene polymerisation
  申请人：Borealis AG

  公开号：EP2746300A1

  公开（公告）日：2014-06-25

  Process for the preparation of a particulate Group 2 metal/transition metal polymerisation catalyst component for ethylene polymerisation comprising a special bi-(oxygen containing ring) compound as internal donor, and to the use of such a catalyst component for preparing a catalyst used in the polymerisation of ethylene.

  制备用于乙烯聚合的颗粒状第 2 族金属/过渡金属聚合催化剂组分的工艺，该催化剂组分包含一种特殊的双（含氧环）化合物作为内部供体，以及使用这种催化剂组分制备用于乙烯聚合的催化剂。
• Supported donor modified Ziegler-Natta catalysts
  申请人：Borealis AG

  公开号：EP2799456A1

  公开（公告）日：2014-11-05

  Procatalyst comprising an inorganic support, a chlorine compound carried on said support, a magnesium compound carried on said support, a titanium compound carried on said support, and a compound comprising two oxygen containg rings, wherein said two rings are linked via a bridge selected from the group conisting of carbon bridge, silicon bridge, ethane-1,2-diyl bridge, ethene-1,2-diyl bridge, alkylaminomethyl bridge and imine bridge.

  催化剂，包括无机载体、载于所述载体上的氯化合物、载于所述载体上的镁化合物、载于所述载体上的钛化合物和由两个含氧环组成的化合物，其中所述两个环通过从碳桥、硅桥、乙烷-1,2-二基桥、乙烯-1,2-二基桥、烷基氨基甲基桥和亚胺桥所组成的组中选出的桥连接。
• Process for producing copolymers of ethylene with alpha-olefins
  申请人：Borealis AG

  公开号：EP3053936A1

  公开（公告）日：2016-08-10

  The present invention is a process for copolymerising ethylene with at least one alpha-olefin having from 4 to 10 carbon atoms in the presence of an olefin polymerisation catalyst comprising a solid catalyst component and an activator, for producing a copolymer of ethylene and the at least one alpha-olefin comonomer having from 4 to 10 carbon atoms. The solid catalyst component comprises magnesium, titanium, halogen and an internal donor. The internal donor is selected from bi-(oxygen containing ring) compounds of formula (I) wherein X is C or Si; R1 can be the same or different and can be hydrogen, a linear or branched C1 to C8-alkyl group, or a C3-C8-alkylene group; and R2 to R5 are the same or different and can be hydrogen, a linear or branched C1 to C8-alkyl, or a C3-C8-alkylene group; and whereby two or more of R1 to R5 can form a ring; n is the same for both oxygen-containing rings and can be 0, 1 or 2; whereby the two oxygen-containing rings can be individually saturated or unsaturated, or an isomer mixture therefrom. The process comprises the steps of: (a) producing a solution comprising a magnesium compound, a titanium compound and the internal donor; (b) combining the solution of step (a) with an alkane or cycloalkane having from 5 to 20 carbon atoms; (c) maintaining the mixture (b) at a temperature of from -20 °C to +50 °C; (d) heating the mixture (b) to a temperature of from 70 to 110 °C to produce a solid component; (e) washing the solid component in at least one washing step to produce the solid catalyst component; (f) polymerising ethylene and the alpha-olefin comonomer having from 4 to 10 carbon atoms in the polymerisation reactor in the presence of the polymerisation catalyst; and (g) recovering the copolymer of ethylene and the alpha-olefin, wherein the copolymer has a comonomer distribution characterised by a Slope Value (SV) of at least 0.8 wherein the Slope Value (SV) is defined as SV=slope+2+branch point length1.25.3 wherein slope is obtained from GPC - IR measurements as defined in the application and the branch point length is CN-2 wherein CN is the number of carbon atoms in the comonomer molecule.

  本发明是一种在由固体催化剂组分和活化剂组成的烯烃聚合催化剂存在下，使乙烯与至少一种具有 4 至 10 个碳原子的α-烯烃共聚的工艺，用于生产乙烯与至少一种具有 4 至 10 个碳原子的α-烯烃共聚物。固体催化剂组分包括镁、钛、卤素和内部供体。内部供体选自式 (I) 的双（含氧环）化合物 其中 X 是 C 或 Si；R1 可以相同或不同，可以是氢、直链或支链 C1 至 C8 烷基或 C3-C8 烯基；R2 至 R5 可以相同或不同，可以是氢、直链或支链 C1 至 C8 烷基或 C3-C8 烯基；其中两个或两个以上的 R1 至 R5 可以形成一个环；n 对两个含氧环来说是相同的，可以是 0、1 或 2；其中两个含氧环可以是单独的饱和环或不饱和环，或其异构体混合物。该工艺包括以下步骤(a) 生成包含镁化合物、钛化合物和内部供体的溶液； (b) 将步骤(a)的溶液与具有 5 至 20 个碳原子的烷烃或环烷烃结合； (c) 将混合物(b)保持在-20 °C 至 +50 °C 的温度下； (d) 将混合物(b)加热至 70 至 110 °C 的温度，生成固体组分；(e) 在至少一个洗涤步骤中洗涤固体组分，生成固体催化剂组分； (f) 在聚合催化剂存在下，在聚合反应器中聚合乙烯和具有 4 至 10 个碳原子的 α-烯烃共聚单体；以及 (g) 回收乙烯和α-烯烃的共聚物，其中共聚物具有共聚单体分布，其特征为斜率值 (SV) 至少为 0.8 其中斜率值 (SV) 定义为 SV=slope+2+branch point length1.25.3 其中斜率根据本申请中定义的 GPC - IR 测量值获得，支点长度为 CN-2 其中 CN 为共聚单体分子中的碳原子数。
• Process for preparing 4-amino-5-biphenyl-4-yl-2-hydroxymethyl-2-methyl-pentanoic acid compound
  申请人：THERAVANCE BIOPHARMA R&D IP, LLC

  公开号：US10011581B2

  公开（公告）日：2018-07-03

  The invention provides processes for preparing intermediates useful for preparing compounds of the formula: or a tautomer or salt thereof, where R1-R5, a, b, X and P2, are as defined in the specification.

  本发明提供了用于制备式化合物的中间体的制备工艺： 或其同系物或盐，其中 R1-R5、a、b、X 和 P2 如说明书中所定义。
• Neprilysin inhibitors
  申请人：THERAVANCE BIOPHARMA R&D IP, LLC

  公开号：US10189823B2

  公开（公告）日：2019-01-29

  In one aspect, the invention relates to compounds having the formula: where X, Ra, Rb, R2, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.

  一方面，本发明涉及具有以下式子的化合物： 其中 X、Ra、Rb、R2 和 R7 如说明书中所定义，或其药学上可接受的盐。这些化合物是具有肾酶抑制活性的化合物的原药。在另一方面，本发明涉及包含这些化合物的药物组合物；使用这些化合物的方法；以及制备这些化合物的工艺和中间体。