6-Fluoro-2-(1,3-thiazol-2-yl)-3,4-dihydro-1lambda6,2-benzothiazine 1,1-dioxide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 6-Fluoro-2-(1,3-thiazol-2-yl)-3,4-dihydro-1lambda6,2-benzothiazine 1,1-dioxide
• 英文别名: 6-fluoro-2-(1,3-thiazol-2-yl)-3,4-dihydro-1λ6,2-benzothiazine 1,1-dioxide
• 化学式: C₁₁H₉FN₂O₂S₂
• 分子量: 284.3
• InChiKey: IWMPEWHXCYJXLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  86.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• CYCLIC SULFONAMIDES AS SODIUM CHANNEL BLOCKERS
  申请人：Purdue Pharma LP

  公开号：EP2935257B1

  公开（公告）日：2018-02-07
• Cyclic Sulfonamides as Sodium Channel Blockers
  申请人：PURDUE PHARMA L.P.

  公开号：US20150336974A1

  公开（公告）日：2015-11-26

  The present disclosure provides cyclic sulfonamides of Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R 1 , R 2 , R 3a , R 3b , and n are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. For example, compounds of the present disclosure are useful for treating pain.
• US9714252B2
  申请人：——

  公开号：US9714252B2

  公开（公告）日：2017-07-25
• [EN] CYCLIC SULFONAMIDES AS SODIUM CHANNEL BLOCKERS<br/>[FR] SULFONAMIDES CYCLIQUES EN TANT QUE BLOQUANTS DES CANAUX SODIQUES
  申请人：PURDUE PHARMA LP

  公开号：WO2014096941A1

  公开（公告）日：2014-06-26

  The present disclosure provides cyclic sulfonamides of Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3a, R3b, and n are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. For example, compounds of the present disclosure are useful for treating pain.