methyl (3R,3aR)-3a,4,5,7-tetrahydro-3H-pyrano[3,4-c][1,2]oxazole-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: methyl (3R,3aR)-3a,4,5,7-tetrahydro-3H-pyrano[3,4-c][1,2]oxazole-3-carboxylate
• 化学式: C₈H₁₁NO₄
• 分子量: 185.18
• InChiKey: XFWOSKGPKMLPHJ-IYSWYEEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] CARBOCYCLIC- AND HETEROCYCLIC-SUBSTITUTED HEXAHYDROPYRANO[3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS<br/>[FR] COMPOSÉS HEXAHYDROPYRANO[3,4-D][1,3]THIAZIN-2-AMINE SUBSTITUÉS CARBOCYCLIQUES ET HÉTÉROCYCLIQUES
  申请人：PFIZER

  公开号：WO2014097038A1

  公开（公告）日：2014-06-26

  The present invention provides compounds of formula (I), wherein the variables R1, R2, R5 and b are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

  本发明提供了式（I）的化合物，其中变量R1、R2、R5和b如规范中定义。相应的药物组合物、治疗方法、合成方法和中间体也被揭示。
• [EN] HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS<br/>[FR] COMPOSÉS HEXAHYDROPYRANO [3,4-D][1,3] THIAZIN-2-AMINE SUBSTITUÉS PAR UN HÉTÉROARYLE
  申请人：PFIZER

  公开号：WO2014125394A1

  公开（公告）日：2014-08-21

  The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, and the variables R1 and R2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.