1-[5-(Dimethylamino)-3-(2-methylsulfonylphenothiazin-10-yl)-5-oxopentyl]piperidine-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 1-[5-(Dimethylamino)-3-(2-methylsulfonylphenothiazin-10-yl)-5-oxopentyl]piperidine-4-carboxylic acid
• 英文别名: 1-[5-(dimethylamino)-3-(2-methylsulfonylphenothiazin-10-yl)-5-oxopentyl]piperidine-4-carboxylic acid
• 化学式: C₂₆H₃₃N₃O₅S₂
• 分子量: 531.7
• InChiKey: IQBJGZVLMBEGAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  132
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• METHODS FOR TREATING GI TRACT DISORDERS
  申请人：Neurogastrx, Inc.

  公开号：EP2934540A1

  公开（公告）日：2015-10-28
• [EN] METHODS FOR TREATING GI TRACT DISORDERS<br/>[FR] MÉTHODES DE TRAITEMENT D'AFFECTIONS DU TRACTUS DIGESTIF
  申请人：NEUROGASTRX INC

  公开号：WO2014105655A1

  公开（公告）日：2014-07-03

  Provided herein are methods, compositions, and kits for the treatment of an enteric nervous system disorder. Such methods may comprise administering to a subject an effective amount of a phenothiazine compound, a peripherally restricted dopamine decarboxylase inhibitor, and/or a peripherally restricted dopamine D2 receptor antagonist that does not substantially inhibit hERG channels
• [EN] PRODRUGS OF METOPIMAZINE<br/>[FR] PROMÉDICAMENTS DE MÉTOPIMAZINE
  申请人：NEUROGASTRX INC

  公开号：WO2015200369A1

  公开（公告）日：2015-12-30

  Provided herein are methods, compounds, compositions, and kits for the treatment of an enteric nervous system disorder. Such methods may comprise administering to a subject an effective amount of a phenothiazine compound, a peripherally restricted dopamine decarboxylase inhibitor, and/or a peripherally restricted dopamine D2 receptor antagonist that does not substantially inhibit hERG channels.