N-[1-[(2R,3S,5R)-3-(2-cyanoethoxymethoxymethoxy)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: N-[1-[(2R,3S,5R)-3-(2-cyanoethoxymethoxymethoxy)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide
• 化学式: C₁₆H₂₂N₄O₈
• 分子量: 398.37
• InChiKey: OOQQKKJQEHJNHZ-HYIGYNPQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  163
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• GLYCOSIDE COMPOUND, METHOD FOR PRODUCING THIOETHER, ETHER, METHOD FOR PRODUCING ETHER, METHOD FOR PRODUCING GLYCOSIDE COMPOUND, METHOD FOR PRODUCING NUCLEIC ACID
  申请人：Aoki Eriko

  公开号：US20140206856A1

  公开（公告）日：2014-07-24

  The invention provides a glucoside compound, which is capable of providing a phosphoramidite, which can be produced at low cost and can produce a nucleic acid in high yield and with high purity. The glycoside compound has the formula wherein B, R 1 , R 2 , and R 3 are as described herein.

  本发明提供了一种葡萄糖苷化合物，能够提供一种磷酰胺酰化物，该磷酰胺酰化物能够以低成本生产，并且能够高产高纯度地产生核酸。该葡萄糖苷化合物具有以下式子：其中B，R1，R2和R3如本文所述。
• GLYCOSIDE COMPOUND, METHOD FOR PRODUCING THIOETHER, ETHER, METHOD FOR PRODUCING ETHER, METHOD FOR PRODUCING GLYCOSIDE COMPOUND, METHOD FOR PRODUCING NUCLEIC ACID
  申请人：Bonac Corporation

  公开号：EP2749565A1

  公开（公告）日：2014-07-02

  Provided is a glucoside compound, which is capable of providing a phosphoramidite, which can be produced at a low cost and can produce a nucleic acid in a high yield and with high purity. A glycoside compound represented by the following chemical formula (1). In the chemical formula (1), B is an atomic group having a nucleic acid base skeleton, and optionally having a protecting group, R1 and R2 are each a hydrogen atom or a protecting group, or R1 and R2 in conjunction optionally form an atomic group represented by the following chemical formula (R1R2A) or (R1R2B): each R1a is a hydrogen atom, a straight chain or branched alkyl group and the like, L1 is an unsubstituted or alkyl-substituted ethylene group, R3 is a group represented by the following chemical formula (R3): in the chemical formula (R3), n is a positive integer, and [D1] is an electron-withdrawing group.

  本发明提供了一种能提供亚磷酰胺的糖苷化合物，它的生产成本低廉，能高产率、高纯度地生产核酸。 由以下化学式（1）代表的糖苷化合物。 在化学式（1）中 B 是具有核酸碱基骨架的原子团，可选择具有保护基团、 R1 和 R2 各为一个氢原子或一个保护基团、 或 R1 和 R2 可选择结合形成由以下化学式（R1R2A）或（R1R2B）表示的原子团： 每个 R1a 是氢原子、直链或支链烷基等、 L1 是未取代的或烷基取代的乙烯基、 R3 是由以下化学式（R3）代表的基团： 在化学式（R3）中 n 为正整数，且 [D1] 是一个抽电子基团。
• THIOETHER COMPOUND FOR THE PROTECTION OF THE 2'-HYDROXY GROUP IN NUCLEOSIDES TO BE USED IN OLIGONUCLEOTIDE SYNTHESIS.
  申请人：Bonac Corporation

  公开号：EP3098230A1

  公开（公告）日：2016-11-30

  An ether is provided which may be used in the production of a glycoside, and method of producing the ether. The ether is represented by the following chemical formula (106): in said chemical formula (106), R4 is a hydrocarbon group, a straight chain or branched alkyl group, a straight chain or branched alkenyl group, a straight chain or branched alkynyl group, an aryl group, a straight chain or branched arylalkyl group, a cycloalkyl group, a cycloalkenyl group, a straight chain or branched cycloalkylalkyl group, a straight chain or branched cyclylalkyl group, or a straight chain or branched alkoxyalkyl group, n is a positive integer, L1 is an ethylene group (-CH2CH2-), wherein hydrogen atoms besides a hydrogen atom bonded to the α-position relative to [D1] are optionally substituted by a straight chain or branched alkyl group, and [D1] is an electron-withdrawing group.

  本发明提供了一种可用于生产苷类的醚以及生产该醚的方法。醚的化学式如下（106）： 在所述化学式（106）中 R4 是烃基、直链或支链烷基、直链或支链烯基、直链或支链炔基、芳基、直链或支链芳烷基、环烷基、环烯基、直链或支链环烷基、直链或支链环炔基、直链或支链烷氧基烷基、 n 为正整数、 L1 是乙烯基（-CH2CH2-），其中除了键合在相对于[D1]的 α 位的氢原子外，其他氢原子可选择被直链或支链烷基取代，以及 [D1] 是一个抽电子基团。
• NUCLEOSIDE PHOSPHORAMIDATES FOR PRODUCING NUCLEIC ACIDS
  申请人：BONAC CORPORATION

  公开号：EP2749565B1

  公开（公告）日：2017-05-31
• US9481702B2
  申请人：——

  公开号：US9481702B2

  公开（公告）日：2016-11-01