Propyl-bis-<2-hydroxy-propyl-(1)>-amin | 20919-81-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Propyl-bis-<2-hydroxy-propyl-(1)>-amin
• 英文别名: ([N,N-(propyl)]amino)bis(propan-2-ol)；bis-(2-hydroxy-propyl)-propyl-amine；1-[2-Hydroxypropyl(propyl)amino]propan-2-ol
• CAS: 20919-81-7
• 化学式: C₉H₂₁NO₂
• mdl: MFCD06252251
• 分子量: 175.271
• InChiKey: VSUZYIMAWHNPOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Propyl-bis-<2-hydroxy-propyl-(1)>-amin 、 1,2-环氧丁烷 以2%的产率得到
  参考文献：
  名称：

  WILK, KAZIMIERA A., POL. J. CHEM., 62,(1988) N-12, C. 895-898

  摘要：

  DOI：
• 作为产物：
  描述：

  methyloxirane 、 N-(2-羟基丙基)丙胺 生成 Propyl-bis-<2-hydroxy-propyl-(1)>-amin
  参考文献：
  名称：

  SLIPKO K.; CHLEBICKI J., POL. J. CHEM., 1979, 53, NO 11, 2231-2237

  摘要：

  DOI：

文献信息

• [EN] TARGETED DELIVERY TO BETA CELLS<br/>[FR] ADMINISTRATION CIBLÉE À DES CELLULES BÊTA
  申请人：CHOUDHARY AMIT

  公开号：WO2018195486A1

  公开（公告）日：2018-10-25

  The disclosure includes zinc prodrugs for targeted delivery of therapeutic, diagnostic or imaging agents to β-cells and methods of use therefor. The disclosure also includes targeted delivery of small molecules to β-cells that stabilize and activate CRISPR effector proteins comprising at least one destabilization domain, to enable CRISPR-based genome editing and transcriptional activation or repression in β-cells.

  本公开内容包括用于将治疗性、诊断性或成像剂靶向递送至β细胞的锌前药及其使用方法。本公开内容还涉及将小分子靶向递送至β细胞，这些小分子能够稳定并激活至少含有一个不稳定域的CRISPR效应蛋白，从而在β细胞中实现基于CRISPR的基因编辑和转录激活或抑制。
• SYNTHESIS OF N-SUBSTITUTED DIISOPROPANOLAMINES, THEIR SEBACATE POLYESTERS AND POLYURETHANE ELASTOMERS
  作者：Jean L. Boivin

  DOI：10.1139/v58-206

  日期：1958.10.1

  Several N-substituted diisopropanolamines were prepared by reacting aqueous solutions of amines with excess propylene oxide at ordinary pressure but higher N-substituted diisopropanolamines had to be prepared in an autoclave at 200 °C. The ionization constants of these bases were measured and recorded as pK_a values. Their infrared absorption spectra gave bands common to all diisopropanolamines mainly at 3.04, 7.14, 7.55, 7.85, 9.45, 10.6, and 11.95 microns. Their condensation with sebacic acid gave the corresponding polyesters, which were soluble in strong acids and had molecular weights of about 1500. The hydroxyl-terminated polyesters were cured with a slight excess of 2,4-tolylene diisocyanate at 100 °C for 2 days to yield elastomers of brittle temperatures in the region of −50 °C.

  通过在常压下，将胺的水溶液与过量的丙烯氧基反应，制备了几种N-取代二异丙醇胺。但是，较高的N-取代二异丙醇胺必须在200°C的高压釜中制备。这些碱的解离常数被测量并记录为pK_a值。它们的红外吸收光谱显示出所有二异丙醇胺共有的频带，主要在3.04、7.14、7.55、7.85、9.45、10.6和11.95微米处。它们与癸二酸的缩聚产物是相应的聚酯，溶解在强酸中，分子量约为1500。羟基终止的聚酯在100°C下与轻微过量的2,4-甲苯二异氰酸酯固化2天，形成具有脆性温度在-50°C左右的弹性体。
• Coordination complexes for detecting analytes, and methods of making and using the same
  申请人：——

  公开号：US20030068275A1

  公开（公告）日：2003-04-10

  The present invention is directed, in part, to coordination complexes for detecting analytes, and methods of making and using the same.

  本发明部分涉及用于检测分析物的配位络合物，以及制备和使用该配位络合物的方法。
• NMR Investigation of the Interaction of Vanadate with Carbasilatranes in Aqueous Solutions
  作者：Evgenios M. Evgeniou、Spyros A. Pergantis、Epameinondas Leontidis、Anastasios D. Keramidas

  DOI：10.1021/ic050929q

  日期：2005.10.1

  bipyramid. Crystal data (Mo Kalpha; 100(2) K) are as follows: orthorhombic space group P2(1)2(1)2(1); a = 8.8751(6), b = 9.7031(7), c = 14.2263(12) A; Z = 4. The complexation of vanadium either with 1 or 2 is stereoselective yielding approximately 94% of the complex containing ligand in the S,R-configuration. The lower ability of the S,S- and R,R-diastereoisomers of 1 and 2 to ligate vanadate was attributed

  钒酸盐与碳硼烷基[甲氧基N，N'，N''-2,2'，3- [双（1-甲基乙醇基）（丙基）]氨基}硅烷（1），甲氧基N，N'，N ''-2,2'，3- [双（1-乙醇乙醇基）（丙基）]氨基}硅烷（2）和N，N'，N''-2,2'，2- [双（乙醇基） ）（乙二醇丙基醚）]氨基}硅烷（3）的水溶液导致形成钒硅酸盐和五配位的螯合钒（V）络合物，如51V，1H和13C NMR光谱所证明。通过X射线衍射表征手性碳纳米管S，S-1处于固态，揭示了金属离子周围的三角双锥几何形状，在轴向位置带有一个不明的甲氧基和一个atrane氮原子，一个碳和两个atat氧在双锥体的赤道平面的原子。晶体数据（Mo Kalpha; 100（2）K）如下：正交空间群P2（1）2（1）2（1）; a = 8.8751（6），b = 9.7031（7），c = 14.2263（12）A; Z =4。钒与1或2的络合物是立体
• Fluorescein-based metal sensors, and methods of making and using the same
  申请人：——

  公开号：US20020106697A1

  公开（公告）日：2002-08-08

  The present invention is directed, in part, to fluorescein-based ligands for detection of metal ions, and methods of making and using the same.

  本发明部分涉及用于检测金属离子的荧光素基配体，以及制备和使用它们的方法。