2-(3-Methylbut-3-enyl)-2-methylsulfanylpurin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-(3-Methylbut-3-enyl)-2-methylsulfanylpurin-6-amine
• 英文别名: 2-(3-methylbut-3-enyl)-2-methylsulfanylpurin-6-amine
• 化学式: C₁₁H₁₅N₅S
• 分子量: 249.34
• InChiKey: FZPOQECWSUNQMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] COMPOSITIONS AND METHODS FOR SYNTHESIS OF PHOSPHORYLATED MOLECULES<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE SYNTHÈSE DE MOLÉCULES PHOSPHORYLÉES
  申请人：UNIV CALIFORNIA

  公开号：WO2019195494A1

  公开（公告）日：2019-10-10

  The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

  这项发明提供了合成磷酸化有机化合物的组合物和方法，包括核苷三磷酸。
• Low sequence bias single-stranded DNA ligation
  申请人：The Penn State Research Foundation

  公开号：US10640828B2

  公开（公告）日：2020-05-05

  The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor molecule with a donor molecule. In one embodiment, the structure of the donor molecule comprises a stem-loop intramolecular nucleotide base pairing (i.e., hairpin) and a 3′-overhang region such that the overhang is able to hybridize to nucleotides present in the 3′ end of the acceptor molecule.

  本发明提供了用于连接单链核酸的组合物和方法，其中连接基于受体分子与供体分子的快速、高效和低序列偏差杂交。在一个实施方案中，供体分子的结构包括茎环分子内核苷酸碱基配对（即发夹）和 3′-悬垂区，使悬垂区能够与受体分子 3′端存在的核苷酸杂交。
• Polymer based signal amplification for protein and cell detection
  申请人：The Penn State Research Foundation

  公开号：US10732175B2

  公开（公告）日：2020-08-04

  The present invention relates generally to compositions, methods and kits for detection of a molecule of interest. The present invention is based, at least in part, on the design of nucleic acid oligonucleotides such that they can be used as molecular building blocks which can be assembled (polymerized) to form a dsDNA polymerization product which can be detected and further, can be disassembled (depolymerized) such that the polymerization product is no longer detectable. The invention can be performed multiple times on the same cell population, and is therefore useful for highly sensitive in situ detection of multiple biomarkers.

  本发明一般涉及用于检测相关分子的组合物、方法和试剂盒。本发明至少部分基于核酸寡核苷酸的设计，使其可用作分子构件，通过组装（聚合）形成可检测的dsDNA聚合产物，并可进一步分解（解聚），使聚合产物不再可检测。本发明可在同一细胞群中多次使用，因此可用于多种生物标记物的高灵敏度原位检测。
• Modification of 3′ terminal ends of nucleic acids by DNA polymerase theta
  申请人：Temple University-Of The Commonwealth System of Higher Education

  公开号：US10865396B2

  公开（公告）日：2020-12-15

  The invention provides compositions and methods for modifying the 3′-terminal ends of nucleic acids using DNA polymerase θ terminal transferase activity.

  本发明提供了利用 DNA 聚合酶 θ 末端转移酶活性修饰核酸 3′-末端的组合物和方法。
• Interferon production using short RNA duplexes
  申请人：Yale University

  公开号：US10947543B2

  公开（公告）日：2021-03-16

  The present invention provides a small hairpin nucleic acid molecule that is capable of stimulating interferon production. The nucleic acid molecule of the present invention has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises a 5′ triphosphate or a 5′ diphosphate.

  本发明提供了一种能够刺激干扰素产生的小发夹核酸分子。本发明的核酸分子具有少于 19 个碱基对的双链部分和至少一个钝末端。在某些实施方案中，该分子包括5′三磷酸或5′二磷酸。