1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine;1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻喃类
• 英文名称: 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine;1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
• 化学式: C41H68N4S
• 分子量: 649.1
• InChiKey: ZOUZYETUQCHLNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.73
• 重原子数：
  46
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PREPARATIONS OF HYDROPHOBIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE AND USE THEREOF
  申请人：Aciex Therapeutics, Inc.

  公开号：EP2941437A1

  公开（公告）日：2015-11-11
• [EN] PREPARATIONS OF HYDROPHOBIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE AND USE THEREOF<br/>[FR] PRÉPARATIONS D'AGENTS THÉRAPEUTIQUES HYDROPHOBES, LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：ACIEX THERAPEUTICS INC

  公开号：WO2014107231A1

  公开（公告）日：2014-07-10

  The present invention further provides method of preparing nanocrystals or microcrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).