Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
申请人:Merck & Co., Inc.
公开号:US06207823B1
公开(公告)日:2001-03-27
The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least one cationic group.
The compounds are represented by formula I:
Pharmaceutical compositions and methods of use are also included.
[EN] TETRAZOLE-FUNCTIONALIZED AMINO ACIDS, THEIR PRODUCTION AND USE<br/>[FR] ACIDES AMINES A FONCTIONNALISATION TETRAZOLE, LEUR PRODUCTION ET LEURS UTILISATIONS
申请人:MEDIGENE AG
公开号:WO2004065372A1
公开(公告)日:2004-08-05
The present invention relates to novel tetrazole-functionalized amino acids of formula (I) and pharmaceutically acceptable salts thereof as well as their production and use.
本发明涉及公式(I)的新型四唑基氨基酸及其药用盐,以及其制备和用途。
Process for the synthesis of carbapenem intermediates, and compounds
申请人:Merck & Co., Inc.
公开号:US06048978A1
公开(公告)日:2000-04-11
A process of synthesizing a carbapenem compound of formula 6: ##STR1## is disclosed using a compound of formula 4': ##STR2## The intermediate compounds that are described herein are also included in the present invention.
Carbapenem antibacterial compounds, compositions containing such
申请人:Merck & Co., Inc.
公开号:US05994343A1
公开(公告)日:1999-11-30
The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a --Z--CH.sub.2 group. The naphthosultam is further substituted with various substituent groups including cationic groups. The compounds are represented by formula I: ##STR1## Pharmaceutical compositions and methods of use are also included.
Penem antibacterial compounds, compositions and methods of treatment
申请人:Merck & Co., Inc.
公开号:US06271222B1
公开(公告)日:2001-08-07
The present invention relates to penem antibacterial agents in which the releaseable liphophilic aromatic side-chain, tethered to the carbapenem nucleus via a methylene linker, necessary for anti-MRSA activity replaces the non-releaseable liphophilic side-chains found in 2-aryl and 2-benzothiazolylthio carbapenem compounds. The compound is further substituted with various substituent groups including at least one cationic group.
The compounds are represented by formula I:
Pharmaceutical compositions and methods of use are also included.