benzyl (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxopentanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: benzyl (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxopentanoate
• 化学式: C₂₇H₂₅NO₅
• 分子量: 443.5
• InChiKey: HONAEBUKTPUROV-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Therapeutic Compounds for Immunomodulation
  申请人：Sasikumar Pottayil G. N.

  公开号：US20140199334A1

  公开（公告）日：2014-07-17

  The present invention provides Immunosuppressive compounds capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The present invention further provides peptide based compositions for treatment of cancer or treatment of infections via immunopotentiation caused by inhibition of immunosuppressive signalling induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient. Further, the invention provides pharmaceutical compositions comprising the Immunosuppressive peptide compounds or modified peptide moieties for preventive and/or therapeutic agents for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of PD-1 or PD-L1 as a testing or diagnostic agent or a research agent for such a disease.

  本发明提供了能够抑制程序性细胞死亡1（PD1）信号通路的免疫抑制化合物。本发明还提供了基于肽的组合物，通过抑制由PD-1，PD-L1或PD-L2诱导的免疫抑制信号而引起免疫增强，用于治疗癌症或感染的治疗方法，包括作为活性成分的免疫增强底物。此外，本发明提供了包含免疫抑制肽化合物或修饰肽基团的药物组合物，用于预防和/或治疗癌症，癌症转移，免疫缺陷，传染病或类似疾病的预防性和/或治疗性剂，并将PD-1或PD-L1应用为测试或诊断剂或用于此类疾病的研究剂。
• Immunosuppression Modulating Compounds
  申请人：Sasikumar Pottayil Govindan Nair

  公开号：US20150087581A1

  公开（公告）日：2015-03-26

  The present invention provides immunosuppression compounds to inhibit the programmed cell death 1 (PD1) signalling pathway. The present invention further provides peptide based compositions for treatment of cancer or treatment of infections via immunopotentiation caused by inhibition of immunosuppressive signaling induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient. Further, the invention provides an application of the compositions containing the peptide moieties for preventive and/or therapeutic agents for cancer, cancer metastasis, immunodeficiency, an infectious disease or the like and an application of peptide moieties as a testing or diagnostic agent or a research agent for such a disease.
• US9096642B2
  申请人：——

  公开号：US9096642B2

  公开（公告）日：2015-08-04