8-benzyl-6-(4-hydroxyphenyl)-2-(naphthalen-2-ylmethyl)-7H-imidazo[1,2-a]pyrazin-3-one | 123437-22-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 8-benzyl-6-(4-hydroxyphenyl)-2-(naphthalen-2-ylmethyl)-7H-imidazo[1,2-a]pyrazin-3-one
• CAS: 123437-22-9
• 化学式: C₃₀H₂₃N₃O₂
• 分子量: 457.532
• InChiKey: AUWMIQYJQMOUJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.71
• 重原子数：
  35.0
• 可旋转键数：
  5.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  70.91
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  1,1-diethoxy-3-(2-naphthalenyl)propan-2-one 、 4-(5-氨基-6-苄基吡嗪-2-基)苯酚 在 盐酸 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 15.0h， 以17.3%的产率得到8-benzyl-6-(4-hydroxyphenyl)-2-(naphthalen-2-ylmethyl)-7H-imidazo[1,2-a]pyrazin-3-one
  参考文献：
  名称：

  Coelenterazine analogs and manufacturing method thereof

  摘要：

  有一种需要具有与已知螺旋藻素类似物不同的发光特性的螺旋藻素类似物。本发明提供了一种由通式（1）表示的化合物。

  公开号：

  US08546568B2

文献信息

• COELENTERAZINE ANALOGS AND MANUFACTURING METHOD THEREOF
  申请人：Inouye Satoshi

  公开号：US20120035070A1

  公开（公告）日：2012-02-09

  There has been a need for coelenterazine analogs that exhibit luminescence properties different from those of known coelenterazine analogs. The present invention provides the compound represented by general formula (1).

  需要一种表现出与已知的共生菌素类似的发光特性的共生菌素类似物。本发明提供了由一般式（1）表示的化合物。
• Synthesis of coelenterazine
  申请人：International Paper Company

  公开号：US11008326B2

  公开（公告）日：2021-05-18

  Disclosed herein are synthesis methods for coelenterazine. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.

  本文公开了腔肠素的合成方法。还公开了包括腔肠素和腔肠素衍生物的物品。具有代表性的吸收物品包括一次性尿布和成人失禁用品。
• SECRETED LUCIFERASE MLUC7 AND USE THEREOF
  申请人：Golz Stefan

  公开号：US20100105090A1

  公开（公告）日：2010-04-29

  The invention relates to the nucleotide and amino acid sequences and to the activity and use of the secreted MLuc7 luciferase.
• LUMINESCENT SUBSTRATE FOR USE IN ARTIFICIAL BIOLUMINESCENT ENZYME
  申请人：NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

  公开号：US20160281129A1

  公开（公告）日：2016-09-29

  The invention relates to a bioluminescent substrate suitably usable in a series of artificial luciferases (ALuc), and the invention provides a wavelength-shifted spectrum with a selective high intensity luminescence and high luminescence stability obtained by the use of the substrate together with ALuc. The luminescent substrate for ALuc obtained by the invention can be included together with a suitable luminescence solution in a luminescence kit. The bioluminescent substrate for ALuc of the invention can exhibit unprecedented excellent luminescence specificity and functionality in the conventional bioluminescence probe, two-hybrid assay, bioluminescent capsule, and reporter gene assay.
• SYNTHESIS OF COELENTERAZINE
  申请人：INTERNATIONAL PAPER COMPANY

  公开号：US20200239471A1

  公开（公告）日：2020-07-30

  Disclosed herein are synthesis methods for coelenterazine. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.