N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methylheptanamide

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methylheptanamide
• 化学式: C₅₅H₉₆N₁₆O₁₃
• 分子量: 1189.5
• InChiKey: SGPYLFWAQBAXCZ-FPICDNEVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  84
• 可旋转键数：
  28
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  491
• 氢给体数：
  18
• 氢受体数：
  18

文献信息

• Polymyxin B-coated nanoparticles
  申请人：Northwestern University

  公开号：US10688195B2

  公开（公告）日：2020-06-23

  Provided herein are antibiotic coated nanoparticles and methods of treating bacterial infection therewith. In particular embodiments, polymyxin B, vancomycin, and/or other antibiotics are linked to nanoparticles (e.g., gold or silica nanoparticles) and utilized for the treatment of bacterial infections.

  本文提供了抗生素涂层纳米粒子以及用其治疗细菌感染的方法。在特定的实施方案中，多粘菌素 B、万古霉素和/或其他抗生素与纳米颗粒（如金或二氧化硅纳米颗粒）相连，用于治疗细菌感染。
• Targeted Therapeutic Nanoparticles
  申请人：nanoDERM Sciences, Inc.

  公开号：US20140199232A1

  公开（公告）日：2014-07-17

  Disclosure of methods and compositions related to chemical conjugations to nanoparticles of polysaccharides cross-linked to poloxamers as well as nano-sized colloids comprised of polysaccharides and poloxamers. The nanoparticles may be produced by various methods including inverse miniemulsion polymerization processes which create nanogels of desired size, shape, and stability for controlled therapeutic drug delivery, imaging, and theragnostic applications.
• TARGETED THERAPEUTIC NANOPARTICLES
  申请人：nanoDERM SCIENCES, INC.

  公开号：US20160106852A1

  公开（公告）日：2016-04-21

  Disclosure of methods and compositions related to chemical conjugations to nanoparticles of polysaccharides cross-linked to poloxamers as well as nano-sized colloids comprised of polysaccharides and poloxamers. The nanoparticles may be produced by various methods including inverse miniemulsion polymerization processes which create nanogels of desired size, shape, and stability for controlled therapeutic drug delivery, imaging, and theragnostic applications.
• METHODS FOR TREATING BACTERIAL INFECTIONS USING ORITAVANCIN AND POLYMYXINS
  申请人：THE MEDICINES COMPANY

  公开号：US20160206687A1

  公开（公告）日：2016-07-21

  Methods of treating bacterial infections in a subject using a synergistic combination of oritavancin and a polymyxin are disclosed.
• ANTIBIOTIC-COATED NANOPARTICLES
  申请人：Northwestern University

  公开号：US20190099500A1

  公开（公告）日：2019-04-04

  Provided herein are antibiotic coated nanoparticles and methods of treating bacterial infection therewith. In particular embodiments, polymyxin B, vancomycin, and/or other antibiotics are linked to nanoparticles (e.g., gold or silica nanoparticles) and utilized for the treatment of bacterial infections.