2-(2-Methylpropyl)-4,5,6,7-tetrahydroisoindole-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(2-Methylpropyl)-4,5,6,7-tetrahydroisoindole-1,3-dione
• 英文别名: 2-(2-methylpropyl)-4,5,6,7-tetrahydroisoindole-1,3-dione
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.27
• InChiKey: NPCOCMQKBKEVQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes
  申请人：California Institute of Technology

  公开号：US10208322B2

  公开（公告）日：2019-02-19

  The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.

  本发明提供了使用血红素酶催化烯烃向任何含有一个或多个环丙烷官能团的化合物转化的方法。在某些方面，本发明提供了一种生产环丙烷化产物的方法，包括提供烯烃底物、重氮试剂和血红素酶；以及在反应中将各组分混合足够长的时间以生产环丙烷化产物。在其他方面，本发明提供了能够进行体内和体外烯烃环丙烷化反应的血红素酶，包括其变体和片段。本发明还提供了表达血红素酶的表达载体和宿主细胞。
• Cytochrome P450 BM3 enzyme variants for preparation of cyclopropanes
  申请人：California Institute of Technology

  公开号：US11008596B2

  公开（公告）日：2021-05-18

  The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.

  本发明提供了利用血红素酶催化烯烃向任何含有一个或多个环丙烷官能团的化合物转化的方法。在某些方面，本发明提供了一种生产环丙烷化产物的方法，包括提供烯烃底物、重氮试剂和血红素酶；以及在反应中将各组分混合足够长的时间以生产环丙烷化产物。在其他方面，本发明提供了能够进行体内和体外烯烃环丙烷化反应的血红素酶，包括其变体和片段。本发明还提供了表达血红素酶的表达载体和宿主细胞。
• AEROSOL FOR CONTROLLING INDOOR INSECT PEST
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20140205548A1

  公开（公告）日：2014-07-24

  The present invention relates to a direct hit type aerosol for controlling an insect pest exhibiting an excellent controlling effect on an insect pest, more specifically an aerosol for controlling an insect pest, comprising at least one pyrethroid compound, at least one organic solvent and at least one propellant, wherein the aerosol characteristic value calculated from the following formula is 0.5-25, Formula): Aerosol characteristic value=Spray arrival distance (cm)×Spraying amount (g) per second/Weight concentration (%) of Pyrethroid compound; and the pyrethroid compound is preferably represented by the formula (I): and more preferably at least one compound selected from the group consisting of imiprothrin, tetramethrin, prallethrin, transfluthrin, metofluthrin, dimefluthrin, 2,3,5,6-tetrafluoro-4-methylbenzyl 2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate and the like.
• IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES
  申请人：California Institute of Technology

  公开号：US20140242647A1

  公开（公告）日：2014-08-28

  The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.
• LIQUID INSECTICIDAL COMPOSITION
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150237863A1

  公开（公告）日：2015-08-27

  The present invention relates to a liquid insecticidal composition containing one or more pyrethroid compounds and two or more organic solvents. The pyrethroid compounds may be, for example, compounds represented by the following formula (I), including 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl=2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate; 4-methyl-2,3,5,6-tetrafluorobenzyl=2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylate; 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl=2,2-dimethyl-3-(2-cyano-1-propenyl)cyclopropanecarboxylate; and the like. wherein R x , R y and R represent the same meaning as defined in the specification. The liquid insecticidal composition is for spraying, has a density of 0.80 g/cm 3 or more and a kinematic viscosity coefficient of 2.0 cSt or more and 6.0 cSt or less, and exhibits an excellent controlling effect on insect pests.